Detection of Cryptococcus neoformans Capsular Antigen in HIV-Infected Patients in the State of Para in the North of Brazil
| Autor: | Lucimar Di Paula dos Santos Madeira, Rosimar Neris Martins Feitosa, Marluísa de Oliveira Guimarães Ishak, Ricardo Ishak, Antonio Carlos Rosário Vallinoto, Silvia Helena Marques da Silva, Maurimélia Mesquita da Costa |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Antigens Fungal HIV Infections Biology Asymptomatic Antigen Virology parasitic diseases Prevalence medicine Humans Hiv infected patients Cryptococcus neoformans AIDS-Related Opportunistic Infections Cryptococcosis T lymphocyte Middle Aged medicine.disease biology.organism_classification Cross-Sectional Studies Infectious Diseases Infectious disease (medical specialty) Capsular antigen Immunology Female medicine.symptom Brazil |
| Zdroj: | Current HIV Research. 11:647-651 |
| ISSN: | 1570-162X |
| DOI: | 10.2174/1570162x12666140311125420 |
| Popis: | Cryptococcus neoformans is an important cause of morbidity in HIV-infected patients worldwide. In the northern region of Brazil, the prevalence of this infection is poorly known due to a lack of systematic investigations. This study aimed to determine the occurrence of cryptococcosis by detecting antigenaemia in HIV-infected patients in the State of Para, Brazil. A latex Cryptococcus antigen detection kit was used to test 418 serum samples from HIV-infected patients seen at two Infectious Disease Specialized Units in the State of Para. The C. neoformans antigenaemia prevalence was 2.6%, and titres reached 1:8. The cases occurred mainly in asymptomatic females, and 45% presented CD4(+) T lymphocyte counts of fewer than 200 cells/mm(3). These results show the importance of early C. neoformans antigenaemia detection to prevent fungal disease. |
| Databáze: | OpenAIRE |
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