The neuritic plaque in Alzheimer's disease: perivascular degeneration of neuronal processes
Autor: | Thuvarahan Jegathees, Glib Popov, Claire Goldsbury, Monica Vogiatzis, Patricia O. Banaczek, Gurpreet Kaur Hansra, Karen M. Cullen |
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Rok vydání: | 2019 |
Předmět: |
Adult
Male 0301 basic medicine Aging Down syndrome Pathology medicine.medical_specialty Neurite Amyloid beta Plaque Amyloid Disease Hippocampal formation 03 medical and health sciences Imaging Three-Dimensional 0302 clinical medicine Alzheimer Disease Neurites medicine Humans Senile plaques Aged Aged 80 and over Neurons biology business.industry General Neuroscience Colocalization Middle Aged medicine.disease 030104 developmental biology medicine.anatomical_structure Microvessels biology.protein Female Neurology (clinical) Geriatrics and Gerontology business Glymphatic System 030217 neurology & neurosurgery Developmental Biology Blood vessel |
Zdroj: | Neurobiology of Aging. 82:88-101 |
ISSN: | 0197-4580 |
Popis: | Cerebrovascular pathology is common in aging and Alzheimer's disease (AD). The microvasculature is particularly vulnerable, with capillary-level microhemorrhages coinciding with amyloid beta deposits in senile plaques. In the current analysis, we assessed the relationship between cerebral microvessels and the neuritic component of the plaque in cortical and hippocampal 50- to 200-μm sections from 11 AD, 3 Down syndrome, and 7 nondemented cases in neuritic disease stages 0-VI. We report that 77%-97% of neuritic plaques are perivascular, independently of disease stage or dementia diagnosis. Within neuritic plaques, dystrophic hyperphosphorylated tau-positive neurites appear as clusters of punctate, bulbous, and thread-like structures focused around capillaries and colocalize with iron deposits characteristic of microhemorrhage. Microvessels within the neuritic plaque are narrowed by 1.0 ± 1.0 μm-4.4 ± 2.0 μm, a difference of 16%-65% compared to blood vessel segments with diameters 7.9 ± 2.0-6.4 ± 0.8 μm (p0.01) outside the plaque domain. The reduced capacity of microvessels within plaques, frequently below patency, likely compromises normal microlocal cerebrovascular perfusion. These data link the neuritic and amyloid beta components of the plaque directly to microvascular degeneration. Strategies focused on cerebrovascular antecedents to neuritic dystrophy in AD have immediate potential for prevention, detection, and therapeutic intervention. |
Databáze: | OpenAIRE |
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