Retrodihydrochalcones and homoisoflavones isolated from Thai medicinal plant Dracaena loureiri and their estrogen agonist activity
| Autor: | Toshiyuki Akiyama, Yasuteru Iijima, Boriboon M, Sachiko Takaishi, Ichikawa K, Motohiko Taki, Kitaoka M |
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| Rok vydání: | 1998 |
| Předmět: |
Magnetic Resonance Spectroscopy
medicine.drug_class Flavonoid Pharmaceutical Science Estrogen receptor Genistein Pharmacognosy Biology Mass Spectrometry Analytical Chemistry chemistry.chemical_compound Chalcone Chalcones Drug Discovery medicine Pharmacology chemistry.chemical_classification Plants Medicinal Traditional medicine Molecular Structure Organic Chemistry Daidzein Biological activity Estrogens biology.organism_classification Thailand Isoflavones Complementary and alternative medicine chemistry Estrogen Molecular Medicine Dracaena |
| Zdroj: | Planta medica. 63(6) |
| ISSN: | 0032-0943 |
| Popis: | Biological evaluation of the extract prepared from the stem wood of Dracaena loureiri, a Thai folkloric medicine called "Chan-daeng", revealed a significant capacity to inhibit [3H]-estradiol binding to the estrogen receptor. During the course of separation, two novel (1 and 2) and two known retrodihydrochalcones (3 and 4), in addition to three known homoisoflavones (5, 6, and 7), were isolated. The structures of compounds 1 and 2 were established by NMR and MS studies by correlating their spectroscopic properties with those of 3 and 4. Each isolate was assessed for its estrogenic activity. Compounds 1 and 6 exhibited activity comparable to that of genistein and daidzein. |
| Databáze: | OpenAIRE |
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