Air Pollutants Interaction and Gender Difference on Bone Mineral Density T-Score in Taiwanese Adults
| Autor: | Bo-Cheng Lai, Chen Feng Wang, Szu-Chia Chen, Hsuan Chiu, Yu Hsuan Lin, Hung-Pin Tu, Pei Yu Wu, Jiun-Chi Huang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Ozone Health Toxicology and Mutagenesis Nitrogen Dioxide Osteoporosis Taiwan Air pollution lcsh:Medicine 010501 environmental sciences medicine.disease_cause 01 natural sciences Article Nitric oxide 03 medical and health sciences chemistry.chemical_compound Sex Factors 0302 clinical medicine Animal science Bone Density Air Pollution medicine Humans Sulfur Dioxide Nitrogen dioxide air pollutants 030212 general & internal medicine NOx 0105 earth and related environmental sciences Bone mineral Carbon Monoxide lcsh:R Public Health Environmental and Occupational Health Middle Aged medicine.disease osteoporosis chemistry gender difference Female Particulate Matter Nitrogen oxide |
| Zdroj: | International Journal of Environmental Research and Public Health, Vol 17, Iss 9165, p 9165 (2020) International Journal of Environmental Research and Public Health Volume 17 Issue 24 |
| ISSN: | 1661-7827 1660-4601 |
| Popis: | Osteoporosis is defined as a systemic skeletal disease characterized by a reduction in bone mass and microarchitectural deterioration of bone tissue. Previous studies have reported associations between air pollution and lower bone mineral density however, few studies have investigated the association between air pollution and osteoporosis. In this study, we combined two databases, the first including 5000 individuals registered in the Taiwan Biobank, and the second containing detailed daily data on air pollution. After multivariable adjustments, ozone (O3) (unstandardized coefficient &beta 0.015 p = 0.008) was significantly positively associated with T-score, whereas carbon monoxide (CO) (unstandardized coefficient &beta &minus 0.809 p < 0.001), sulfur dioxide (SO2) (unstandardized coefficient &beta 0.050 p = 0.005), nitric oxide (NO) (unstandardized coefficient &beta 0.040 0.001), nitrogen dioxide (NO2) (unstandardized coefficient &beta 0.023 0.001), and nitrogen oxide (NOx) (unstandardized coefficient &beta 0.017 0.001) were significantly negatively associated with T-score. The interactions between CO and NOx (p = 0.001) and SO2 and NO2 (p = 0.004) on T-score were statistically significant. An increase in exposure to CO, NO and NOx was associated with a faster decline in T-score in the female participants compared to the male participants. In addition, an increase in O3 was associated with a faster increase in T-score in the female participants compared to the male participants. In conclusion, the air pollutants CO, SO2, NO, NO2, and NOx were associated with osteoporosis. In addition, there were interaction and synergetic effects between CO and NOx and SO2 and NO2 on T-score. We also observed differences in the associations between air pollutants and T-score between the female and male participants. |
| Databáze: | OpenAIRE |
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