Possible mechanisms of antinociception of methanol extract of Melastoma malabathricum leaves
| Autor: | Mohd Nasir Mohd Desa, Z. A. Zakaria, Arifah Abdul Kadir, Erman Shah Jaios, Siew Mooi Ching, Suzana Abdul Rahman |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.drug_class lcsh:RS1-441 (+)-Naloxone Pharmacology Nitric oxide lcsh:Pharmacy and materia medica Pain-killing Pharmacology Toxicology and Pharmaceutics(all) 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine General Pharmacology Toxicology and Pharmaceutics Melastoma malabathricum Natural products biology Chemistry Drug discovery biology.organism_classification 030104 developmental biology Nociception Opioid Capsaicin Herbal Licking 030217 neurology & neurosurgery Opioid antagonist Melastomaceae medicine.drug |
| Zdroj: | Revista Brasileira de Farmacognosia, Volume: 26, Issue: 5, Pages: 586-594, Published: OCT 2016 Revista Brasileira de Farmacognosia, Vol 26, Iss 5, Pp 586-594 Revista Brasileira de Farmacognosia v.26 n.5 2016 Revista Brasileira de Farmacognosia Sociedade Brasileira de Farmacognosia (SBFgnosia) instacron:SBFGNOSIA Revista Brasileira de Farmacognosia, Vol 26, Iss 5, Pp 586-594 (2016) |
| Popis: | Melastoma malabathricum L., Melastomaceae, has been traditionally used to relieve diverse pain-related ailments. The objectives of the present study were to determine the antinociceptive activity of methanol extract of M. malabathricum leaves and to elucidate the possible mechanisms of antinociception involved using various rats’ models. The extract (100, 250, and 500 mg/kg) was administered orally 60 min prior to subjection to the respective test. The in vivo acetic acid-induced abdominal constriction, formalin-induced paw licking, and hot plate tests were used as the models of nociception to evaluate the extract antinociceptive activity. Further studies were carried out to determine the role of opioid and vanilloid receptors, glutamate system and nitric oxide/cyclic guanosine phosphate (NO/cGMP) pathway in modulating the extract antinociceptive activity. From the results obtained, M. malabathricum exhibited significant (p |
| Databáze: | OpenAIRE |
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