A New Ene-triyne Antibiotic from the Fungus Baeospora myosura
| Autor: | Gonzalo Platas, Craig A. Parish, Jenny M. Baxter, Javier Collado, Joann Huber, Karen Dorso, George K. Abruzzo, Antonio Gonzalez, Francisca Vicente, Maria Teresa Diez, Kenneth E. Wilson |
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| Rok vydání: | 2004 |
| Předmět: |
Staphylococcus aureus
Polymers Stereochemistry Gram-positive bacteria Pharmaceutical Science Microbial Sensitivity Tests Gram-Positive Bacteria medicine.disease_cause Analytical Chemistry Microbiology chemistry.chemical_compound Baeospora myosura Candida albicans Gram-Negative Bacteria Drug Discovery medicine Nuclear Magnetic Resonance Biomolecular Antibacterial agent Pharmacology Natural product biology Acetylene Basidiomycota Organic Chemistry Polyynes biology.organism_classification Antimicrobial Yeast Anti-Bacterial Agents Complementary and alternative medicine chemistry Molecular Medicine Oxidation-Reduction Bacteria |
| Zdroj: | Journal of Natural Products. 67:1900-1902 |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/np0497853 |
| Popis: | The isolation and structure elucidation of 1 from the Basidomycete fungus Baeospora myosura is described. This new ene-triyne antibiotic was most potent against Gram-positive bacteria, while it was less active against Gram-negative bacteria and a yeast. MICs against several strains of Staphylococcus aureus were as low as 0.001 microg/mL. Analogues of 1 that did not contain the ene-triyne moiety were inactive against all microorganisms tested. The isolation of this new natural product was complicated by the highly reactive nature of the conjugated terminal polyacetylene. |
| Databáze: | OpenAIRE |
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