Glucocorticoids use in kidney transplant setting
| Autor: | Débora Dias de Lucena, Erika B Rangel |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
030232 urology & nephrology
030230 surgery Toxicology Bioinformatics Risk Assessment Kidney transplant 03 medical and health sciences 0302 clinical medicine Steroid avoidance Pharmacokinetics Risk Factors Animals Humans Medicine Drug Interactions Adverse effect Glucocorticoids Randomized Controlled Trials as Topic Pharmacology Dose-Response Relationship Drug business.industry General Medicine Kidney Transplantation Early Diagnosis Pharmacodynamics business Immunosuppressive Agents |
| Zdroj: | Expert Opinion on Drug Metabolism & Toxicology. 14:1023-1041 |
| ISSN: | 1744-7607 1742-5255 |
| DOI: | 10.1080/17425255.2018.1530214 |
| Popis: | Despite major advances in kidney transplant, glucocorticoids (GCs) or steroids remain one of the mainstay treatments. They possess adverse events (AEs) that are related to cumulative dosage, as documented in experimental and clinical studies. Therefore, it is important to comprehend and interpret experimental data and equally important to critically review clinical studies. Areas covered: This article provides a broad overview of the structure, pharmacokinetics, and pharmacodynamics of systemically administered GCs in transplant setting. It further discusses at length the results of in vitro and pre-clinical studies, as well as steroid avoidance (SA) or withdrawal (SW)-based clinical studies. We summarized the main AEs and discussed the alternatives to minimize these events. Some clinically relevant drug-drug interactions are also highlighted. Expert opinion: Although SA/SW in kidney transplant is a desirable strategy due to its AEs, there is no evidence to support that strategy based on the available data, despite some encouraging reports. Furthermore, early diagnosis and treatment of GC-induced AEs seem to be the most efficacious strategies. Likewise, some risks factors predate transplant and could be used to risk-stratify patients to determine appropriate risk-reduction strategies. Additional randomized-controlled studies are required to assess the impact of SA/SW during short and long follow-ups.ACTH: Adrenocorticotropic hormone (also adrenocorticotropin and corticotropin); ADA: American Diabetes Association; AEs: Adverse events; ADX: Adrenalectomized; AR: Acute rejection; AUC: Area under the curve; BMI: Body mass index; BMD: Bone mineral density; BPAR: Biopsy-proven acute rejection; cAMP: cyclic adenosine monophospahte; CBG: Corticosteroid-binding globulin; CBP: CREB binding protein; C |
| Databáze: | OpenAIRE |
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