Immunohistochemical expression of somatostatin type 2A receptor in neuroendocrine carcinoma of uterine cervix
| Autor: | Hiroshi Kajiwara, Kenichi Hirabayashi, Mikio Mikami, Takeshi Hirasawa, Toshinari Muramatsu, Masaki Miyazawa, Masanori Yasuda, Naoya Nakamura, Robert Yoshiyuki Osamura |
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| Jazyk: | angličtina |
| Předmět: |
Adult
medicine.medical_specialty Synaptophysin Uterine Cervical Neoplasms Neuroendocrine tumors Young Adult Cervical Neuroendocrine Carcinoma Internal medicine Obstetrics and Gynaecology medicine Somatostatin receptor 2 Humans Receptors Somatostatin Neural Cell Adhesion Molecules Aged biology Somatostatin receptor business.industry Large cell Obstetrics and Gynecology Chromogranin A General Medicine Middle Aged medicine.disease Immunohistochemistry Carcinoma Neuroendocrine Somatostatin Endocrinology Cancer research biology.protein Female business Biomarkers |
| Zdroj: | Archives of Gynecology and Obstetrics. 279(4):521-525 |
| ISSN: | 0932-0067 |
| DOI: | 10.1007/s00404-008-0760-y |
| Popis: | Somatostatin and its analogues inhibit the growth of various kinds of endocrine and exocrine cells via the somatostatin receptor (SSTR). Expression of SSTR2A has been reported in many well-differentiated neuroendocrine tumors and small numbers of poorly differentiated neuroendocrine carcinomas. SSTR2A-positive neuroendocrine tumors may be treatable by SS analogues. Uterine cervical neuroendocrine carcinoma is generally associated with poor prognosis. We examined the expression of SSTR2A and other neuroendocrine markers [neural cell adhesion molecule (NCAM), chromogranin A, and synaptophysin] by immunohistochemical methods in seven neuroendocrine tumors of the uterine cervix: five small cell carcinomas and two large cell neuroendocrine carcinomas. SSTR2A was expressed in one small cell carcinoma and two neuroendocrine large cell carcinomas. The cell membrane of cells in these carcinomas showed strong immunohistochemical reactivity for SSTR2A. SSTR2A-positive cases are also frequently positive for the expression of chromogranin A. Treatment with SSTR2A may be effective for endocrine tumors. The results indicate the usefulness of SSTR2A analogs for the treatment of some uterine neuroendocrine carcinomas. |
| Databáze: | OpenAIRE |
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