Association between stimulated plasma C-peptide and age: the Wadena City Health Study
| Autor: | L. Ronald French, J. Michael Sprafka, Frederick C. Goetz, Anita M. Martinez, Sally A. Bushhouse, James R. Boen |
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| Rok vydání: | 1992 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Aging medicine.medical_treatment Lipoproteins Minnesota Population Urine Fatty Acids Nonesterified Body Mass Index chemistry.chemical_compound Eating Hemoglobins Sex Factors Predictive Value of Tests Internal medicine Blood plasma medicine Humans Least-Squares Analysis education Triglycerides Aged Glycated Hemoglobin Creatinine education.field_of_study C-Peptide C-peptide business.industry Insulin Age Factors Fasting Middle Aged Endocrinology Blood pressure Cholesterol Cross-Sectional Studies chemistry Linear Models Female Geriatrics and Gerontology business Body mass index |
| Zdroj: | Journal of the American Geriatrics Society. 40(4) |
| ISSN: | 0002-8614 |
| Popis: | Objective To assess age-related changes in stimulated plasma C-peptide in a population-based sample of adults. Design Cross-sectional study. Setting Wadena, Minnesota, a city of 4,699 residents (1980 census) in west central Minnesota, approximately 150 miles from Minneapolis/St. Paul. Study Subjects 344 non-diabetic subjects (NDDG standards) from a stratified random sample of the total adult population of Wadena, MN. The six-study strata were men and women from three age groups: young, 20–39 years of age; middle-aged, 40–59; and older, >60 years of age. Measurements During a liquid meal of Ensure-Plus (Ensure-Plus® challenge test; EPCT; Ross Laboratories), blood samples were taken for glucose, free fatty acids, creatinine, and C-peptide. Plasma C-peptide taken 90 minutes after the EPCT was used as a surrogate measure for insulin. Clinical tests included one-time samples for hemoglobin, glycosylated hemoglobin, plasma cholesterol, triglycerides, and lipoproteins. Physical measurements included height, weight, and blood pressure. Urine was assayed for C-peptide and creatinine. Assays of urine and plasma C-peptide used antibody M1221 (from Novo; Copenhagen, Denmark). Main Results No differences were observed for the relationship between age and C-peptide within each of the three age groups for men and the three age groups for women. However, the levels of plasma C-peptide for older men or women were statistically significantly higher than levels for the young age groups of the same sex; fasting plasma glucose also was higher for older groups of both sexes, and postmeal glucose was significantly higher for older women. There were decreases with age in urine C-peptide clearance for women and men; the decline for women was statistically significant. In multiple regression models for men alone and women alone, that controlled for age, post-meal plasma glucose best explained plasma C-peptide levels. For young men, plasma glucose alone provided the best prediction of plasma C-peptide levels; body mass index (BMI) and plasma glucose provided the best prediction for young women. For older men and both middle-aged and older women, a combination of urine C-peptide clearance and plasma glucose best predicted plasma C-peptide levels; for middle-aged men, BMI also contributed to the prediction. Conclusions Secretion of insulin in response to an orally administered mixed meal is undiminished with age in non-diabetic adults. |
| Databáze: | OpenAIRE |
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