Comparison of Absorption of Cortisone Acetate and Hydrocortisone Hemisuccinate*
| Autor: | Peter H. Forsham, Jeanette Shinsako, Satoshi Hane, Bruce L. Fariss |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Adult
medicine.medical_specialty Hydrocortisone Endocrinology Diabetes and Metabolism medicine.medical_treatment Clinical Biochemistry Administration Oral Adrenocorticotropic hormone Injections Intramuscular Biochemistry Absorption Cushing syndrome Route of administration Endocrinology Adrenocorticotropic Hormone Internal medicine medicine Adrenal insufficiency Humans Cushing Syndrome Aged business.industry Adrenalectomy Biochemistry (medical) Middle Aged medicine.disease Cortisone Addison's disease Female business medicine.drug |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 47:1137-1140 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jcem-47-5-1137 |
| Popis: | In four patients who required maintenance glucocorticoid therapy after bilateral adrenalectomy for Cushing's disease, we compared the effects of im injection and oral ingestion of cortisone acetate and hydrocortisone hemisuccinate. By the former route of administration, cortisone acetate was not effective in elevating plasma cortisol levels or in suppressing plasma adrenocorticotropin, although hydrocortisone was. When given by mouth, no significant difference was found between the two steroids. Therefore, in the treatment of acute adrenal insufficiency or in the maintenance of patients with chronic adrenal insufficiency and in their preparation for surgery or other stressful situations, we advise against im injection of cortisone acetate. Oral ingestion, however, is appropriate for maintenance. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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