Long QT syndrome is associated with an increased burden of diabetes, psychiatric and neurological comorbidities:a nationwide cohort study
| Autor: | Peter Weeke, Christian Torp-Pedersen, Charlotte Andersson, Jørgen K. Kanters, Jacob Tfelt-Hansen, Peter Marstrand, Juliane Theilade, Gunnar Gislason, Camilla H Jespersen, Henning Bundgaard, Mads E. Jørgensen |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
congenital hereditary and neonatal diseases and abnormalities Long QT syndrome Population Epilepsy medicine long QT syndrome cardiovascular diseases Psychiatry education hearing loss education.field_of_study diabetes business.industry Retrospective cohort study medicine.disease Comorbidity Special Populations comorbidity Cohort Etiology epilepsy Cardiology and Cardiovascular Medicine business Cohort study |
| Zdroj: | Marstrand, P, Theilade, J, Andersson, C, Bundgaard, H, Weeke, P E, Tfelt-Hansen, J, Jespersen, C, Gislason, G, Torp-Pedersen, C, Kanters, J K & Jørgensen, M E 2019, ' Long QT syndrome is associated with an increased burden of diabetes, psychiatric and neurological comorbidities : a nationwide cohort study ', Open Heart, vol. 6, no. 2, e001161 . https://doi.org/10.1136/openhrt-2019-001161 Marstrand, P, Theilade, J, Andersson, C, Bundgaard, H, Weeke, P E, Tfelt-Hansen, J, Jespersen, C, Gislason, G, Torp-Pedersen, C, Kanters, J K & Jørgensen, M E 2019, ' Long QT syndrome is associated with an increased burden of diabetes, psychiatric and neurological comorbidities : A nationwide cohort study ', Open Heart, vol. 6, no. 2, e001161 . https://doi.org/10.1136/openhrt-2019-001161 Open Heart |
| Popis: | ObjectiveStudies have suggested a shared genetic aetiology between congenital long QT syndrome (LQTS) and diabetes, epilepsy and mental disorders. We investigated the prevalence of metabolic, neurological and psychiatric comorbidities in LQTS patients.MethodsThis retrospective cohort study was based on data from nationwide Danish registries, 2003–2017. LQTS patients were matched 1:5 with controls on sex and age.ResultsWe matched 463 LQTS patients with 2315 controls from the background population. Mean age was 35.7 (SD 21.0) years, and 38% were males in both groups. LQTS patients had a higher prevalence of atrial fibrillation (6.5% vs 2.3%, pConclusionsIn this nationwide cohort, patients with LQTS had a significantly increased burden of diabetes, neurological and psychiatric comorbidities, compared with the background population. The higher prevalence of neurological comorbidities was largely driven by epilepsy, despite a high rate of potentially misdiagnosed patients prior to LQTS diagnosis. Our data support that LQTS may be considered a multiorgan disease and suggest that patient management should be adjusted accordingly. |
| Databáze: | OpenAIRE |
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