Cell-Based Nanoparticles Delivery Systems for Targeted Cancer Therapy: Lessons from Anti-Angiogenesis Treatments

Autor: Ana I. Flores, Alvaro Alcazar-Garrido, Paz de la Torre, Maria Jesus Perez-Lorenzo
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Cell type
Angiogenesis
medicine.medical_treatment
Pharmaceutical Science
Antineoplastic Agents
02 engineering and technology
Review
exosomes
Analytical Chemistry
lcsh:QD241-441
03 medical and health sciences
angiogenesis
Drug Delivery Systems
lcsh:Organic chemistry
Neoplasms
Drug Discovery
medicine
cancer
Animals
Humans
Physical and Theoretical Chemistry
030304 developmental biology
0303 health sciences
Chemotherapy
Tumor microenvironment
mesenchymal stem cells
Drug Carriers
cell membrane coating
nanotechnology
Neovascularization
Pathologic
business.industry
hypoxia
Organic Chemistry
Mesenchymal stem cell
021001 nanoscience & nanotechnology
nanomedicine
Microvesicles
Chemistry (miscellaneous)
Cancer research
Molecular Medicine
Nanomedicine
Nanoparticles
0210 nano-technology
business
Homing (hematopoietic)
Zdroj: Molecules
Molecules, Vol 25, Iss 3, p 715 (2020)
ISSN: 1420-3049
Popis: The main strategy of cancer treatment has focused on attacking the tumor cells. Some cancers initially responsive to chemotherapy become treatment-resistant. Another strategy is to block the formation of tumor vessels. However, tumors also become resistant to anti-angiogenic treatments, mostly due to other cells and factors present in the tumor microenvironment, and hypoxia in the central part of the tumor. The need for new cancer therapies is significant. The use of nanoparticle-based therapy will improve therapeutic efficacy and targeting, while reducing toxicity. However, due to inefficient accumulation in tumor sites, clearance by reticuloendothelial organs and toxicity, internalization or conjugation of drug-loaded nanoparticles (NPs) into mesenchymal stem cells (MSCs) can increase efficacy by actively delivering them into the tumor microenvironment. Nanoengineering MSCs with drug-loaded NPs can increase the drug payload delivered to tumor sites due to the migratory and homing abilities of MSCs. However, MSCs have some disadvantages, and exosomes and membranes from different cell types can be used to transport drug-loaded NPs actively to tumors. This review gives an overview of different cancer approaches, with a focus on hypoxia and the emergence of NPs as drug-delivery systems and MSCs as cellular vehicles for targeted delivery due to their tumor-homing potential.
Databáze: OpenAIRE
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