Increased pulse wave velocity in patients with panic disorder: independent vascular influence of panic disorder on arterial stiffness
| Autor: | İsmail Şahin, Yüksel Çiçek, Mustafa Çetin, Turan Erdoğan, Hulya Guveli, Murtaza Emre Durakoğlugil, Aytun Çanga, Sinan Altan Kocaman, Sıtkı Doğan |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Blood Pressure Pulse Wave Analysis Sudden cardiac death Vascular Stiffness Heart Rate Internal medicine Heart rate medicine Humans Myocardial infarction Pulse wave velocity business.industry Panic disorder Middle Aged medicine.disease Femoral Artery Psychiatry and Mental health Clinical Psychology Blood pressure Carotid Arteries Cross-Sectional Studies Pulsatile Flow Arterial stiffness Cardiology Panic Disorder Female business Anxiety disorder Blood Flow Velocity |
| Zdroj: | Journal of psychosomatic research. 73(2) |
| ISSN: | 1879-1360 |
| Popis: | Objective Acute and chronic mental stress and many psychiatric disorders have been accepted as a cause of cardiovascular disease. Panic disorder, a subtype of anxiety disorder, has been associated with increased risk of fatal myocardial infarction and sudden cardiac death in epidemiological studies. Carotid–femoral pulse wave velocity (CF-PWV) is currently the gold standard measurement of arterial stiffness. CF-PWV is a well-recognized predictor of an adverse cardiovascular outcome with higher predictive value than classical cardiovascular risk factors. The aim of our study is to measure PWV as the surrogate of arterial stiffness and vascular involvement in patients with panic disorder. Methods Forty-two patients with PD, and 30 control participants were included in the study. Patients with hypertension, diabetes mellitus, or the history of any cardiovascular disease were excluded from study. Results Baseline characteristics were not significantly different between the two groups, except carotid–femoral pulse wave velocity (PD vs. control; 7.51 ± 2.02 vs. 6.24 ± 1.09 m/s, p = 0.001), heart rate, and smoking status. Additionally, CF-PWV positively correlated with age (r = 0.250, p = 0.034), heart rate (r = 0.284, p = 0.017), systolic and diastolic blood pressure (r = 0.393, p = 0.001 and r = 0.286, p = 0.015, respectively) significantly. However, only the presence of panic disorder was independently related to PWV (βeta: 0.317, p = 0.011) in the multivariate analysis including age, heart rate, smoking status and blood pressure measurements. Conclusion Increased pulse wave velocity in patients with panic disorder may justify the associated risk as documented in previous studies, and may be useful in identifying the patients with higher risk of future cardiovascular complications. |
| Databáze: | OpenAIRE |
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