Impaired learning and memory in mice induced by nano neodymium oxide and possible mechanisms
| Autor: | Yang Liu, Qianru Ye, Tao Wu, Hongxing Fan, Jing Yang, Dantong Jia, Gang Wu, Ning Yang, Le Ji |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Health Toxicology and Mutagenesis Morris water navigation task 010501 environmental sciences Management Monitoring Policy and Law Toxicology medicine.disease_cause 01 natural sciences Hippocampus Superoxide dismutase 03 medical and health sciences chemistry.chemical_compound Mice 0302 clinical medicine Memory Internal medicine medicine Hippocampus (mythology) Animals Learning Maze Learning 0105 earth and related environmental sciences chemistry.chemical_classification Neodymium Reactive oxygen species Mice Inbred ICR biology Superoxide Dismutase Oxides General Medicine Glutamic acid Malondialdehyde Endocrinology chemistry 030220 oncology & carcinogenesis Amino acid neurotransmitter biology.protein Female Oxidative stress |
| Zdroj: | Environmental toxicologyREFERENCES. 36(8) |
| ISSN: | 1522-7278 |
| Popis: | A growing number of individuals are now exposed to neodymium (Nd) owing to its extensive applications. However, the biological effects of Nd on humans, especially on learning and memory, remain elusive. To investigate whether Nd exposure affects learning and memory, in this study female ICR mice were exposed to nano Nd2 O3 via intranasal instillation at doses of 50, 100, and 150 mg/kg body weight, daily for 45 days. According to Morris water maze data, learning and memory parameters were significantly reduced in the 150 mg/kg nano-Nd2 O3 group than the sham control. Furthermore, inductively coupled plasma-mass spectroscopy analysis revealed that Nd levels were significantly higher in the hippo campus of the 100 and 150 mg/kg exposed group than the sham control; however, no significant differences were observed in the hippocampal histopathology between these groups. Furthermore, reactive oxygen species were elevated in hippocampal tissues of experimental groups than the sham control, 447.3 in high dose group and 360.0 in control group; however, malondialdehyde levels were significantly increased and superoxide dismutase activities were decreased only in mice exposed to 100 and 150 mg/kg Nd2 O3 . High-performance liquid chromatography data demonstrated that levels of glutamic acid, glycine, and gamma-aminobutyric acid were higher in the hippocampus of mice exposed to 150 mg/kg Nd2 O3 than the sham control. Our findings indicated that the neuronal injury was induced by disruption of the oxidation-antioxidation homeostasis and altered amino acid neurotransmitter levels in the hippocampus, which could result in the poor cognitive performance demonstrated by exposed mice. |
| Databáze: | OpenAIRE |
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