Improving adherence to ticagrelor in patients after acute coronary syndrome: Results from the progress trial
| Autor: | Felice Gragnano, Marco Di Maio, Arturo Cesaro, Elisabetta Moscarella, Plinio Cirillo, Claudia Concilio, Paolo Calabrò, Dario Di Maio, Fabio Fimiani, Mario Crisci, Vittorio Taglialatela, Ivana Pariggiano, Vincenzo Diana |
|---|---|
| Přispěvatelé: | Crisci, M., Gragnano, F., Di Maio, M., Diana, V., Moscarella, E., Pariggiano, I., Di Maio, D., Concilio, C., Taglialatela, V., Fimiani, F., Cesaro, A., Cirillo, P. L., Calabro, P., Crisci, Mario, Gragnano, Felice, Di Maio, Marco, Diana, Vincenzo, Moscarella, Elisabetta, Pariggiano, Ivana, Di Maio, Dario, Concilio, Claudia, Taglialatela, Vittorio, Fimiani, Fabio, Cesaro, Arturo, Cirillo, Plinio Lorenzo, Calabrò, Paolo |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Acute coronary syndrome medicine.medical_specialty Ticagrelor Outpatient Clinics Hospital Time Factors Hemorrhage 030204 cardiovascular system & hematology Drug Administration Schedule law.invention Medication Adherence 03 medical and health sciences Appointments and Schedules 0302 clinical medicine Percutaneous Coronary Intervention Randomized controlled trial law Internal medicine medicine Clinical endpoint Outpatient clinic Humans In patient Prospective Studies Aged 030203 arthritis & rheumatology Pharmacology Aspirin business.industry Dual Anti-Platelet Therapy Bleeding Middle Aged medicine.disease Discontinuation Telephone Treatment Outcome Italy Adherence Dual antiplatelet therapy Disruption Female Cardiology and Cardiovascular Medicine business Platelet Aggregation Inhibitors medicine.drug |
| Popis: | Background: Dual antiplatelet therapy (DAPT) with aspirin and ticagrelor is recommended for at least 12 months in patients after an acute coronary syndrome (ACS). However, its underuse and premature discontinuation are common in clinical practice. We aimed to investigate the impact of a dedicated follow-up strategy with clinical visits and counselling on adherence levels to ticagrelor in patients after ACS. Methods: PROGRESS (PROmotinG dual antiplatelet therapy adheREnce in the setting of acute coronary Syndromes) is a prospective, randomized trial enrolling 400 ACS patients treated with ticagrelor. Patients were randomized to be followed-up in a dedicated outpatient clinic (In-person follow-up group, [IN-FU], n=200), or with scheduled for phone interviews only (Telephone follow-up group [TEL-FU], n=200), to assess ticagrelor adherence and related complications. DAPT disruption was defined as an interruption of the administration of the drug due to complications or other reasons of non-adherence, and divided according to the duration into short (1-5 days), temporary (6-30 days) and permanent (≥30 days) disruption. The primary endpoint was the rate of DAPT disruption at 1-year follow-up. Results: The rate of ticagrelor disruption at 1 year follow-up was higher in the TEL-FU group than in the IN-FU group (19.6 vs 5.5%; p Conclusion: The PROGRESS trial showed a net reduction in DAPT disruption in patients followed-up with clinical (in-person) follow-up visits in a dedicated outpatient clinic compared with those scheduled for phone interviews only. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|