Infection control management and surveillance of carbapenem-resistant Gram-negative bacteria in hematopoietic stem cell recipients

Autor: Stefan Ziesing, Matthias Eder, V Panagiota, Daniel Kharazipour, Robin Bollin, Sophie Charlotte Hintze, Gernot Beutel, Catherina Lueck, Maleen Beck, Claas Baier, Franz-Christoph Bange, Ella Ebadi
Rok vydání: 2019
Předmět:
0301 basic medicine
Microbiology (medical)
Colonization
Adult
Male
medicine.medical_specialty
medicine.drug_class
Carbapenem resistance
medicine.medical_treatment
030106 microbiology
Antibiotics
Short Report
Context (language use)
Drug resistance
Hematopoietic stem cell transplantation
Bloodstream infection
beta-Lactam Resistance
lcsh:Infectious and parasitic diseases
03 medical and health sciences
0302 clinical medicine
Medical microbiology
Internal medicine
Gram-Negative Bacteria
medicine
Prevalence
Infection control
Humans
Pharmacology (medical)
lcsh:RC109-216
Public Health Surveillance
Aged
Infection Control
biology
Transmission (medicine)
business.industry
Public Health
Environmental and Occupational Health
Hematopoietic Stem Cell Transplantation
Middle Aged
biology.organism_classification
Transplant Recipients
Acinetobacter baumannii
Anti-Bacterial Agents
Infectious Diseases
Carbapenems
Screening
Female
business
Gram-Negative Bacterial Infections
030215 immunology
Zdroj: Antimicrobial Resistance and Infection Control, Vol 8, Iss 1, Pp 1-5 (2019)
Antimicrobial Resistance and Infection Control
ISSN: 2047-2994
Popis: Hematopoietic stem cell transplantation (HSCT) is a curative treatment option for selected diseases of the hematopoietic system. In the context of HSCT, bloodstream infections caused by Gram-negative bacteria (GNB) significantly contribute to morbidity and mortality. Antibiotic treatment of bloodstream infections with carbapenem-resistant (CR) GNB presents a particular challenge. As a part of our infection control management, the admission of a patient who was known to be colonized with a CR Acinetobacter baumannii triggered an active weekly screening of all patients to determine the prevalence and potential transmission of CR GNB and CR Acinetobacter baumannii in particular. Over a 3 month period a total of 71 patients were regularly screened for colonization with CR GNB. Including the index patient, a total of three patients showed CR GNB colonization representing a prevalence of 4.2%. Nosocomial transmission of CR Acinetobacter baumannii or other CR GNB was not observed. However, the index patient developed a subsequent bloodstream infection with the CR Acinetobacter baumannii, therefore empiric antibiotic therapy based on the known resistance profile was initiated. A weekly prevalence screening for CR GNB might be an effective monitoring tool for potential transmission, may enhance existing infection control management concepts and may support the decision making for empiric antibiotic therapy.
Databáze: OpenAIRE
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