Exposure of hemodialysis patients to di-2-ethylhexyl phthalate
| Autor: | Micheline Cazin, M. Luyckx, D Pagniez, Jean-Claude Cazin, Thierry Dine, Bernard Gressier, K. Kambia, My El Abbes Faouzi, A Belabed, Claude Brunet |
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| Rok vydání: | 1999 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Time Factors medicine.medical_treatment Pharmaceutical Science chemistry.chemical_compound Renal Dialysis Diethylhexyl Phthalate Internal medicine medicine Humans Renal Insufficiency Dialysis Aged Chromatography Triglyceride Chemistry Cholesterol Phthalate Lipid metabolism Middle Aged medicine.disease Endocrinology Toxicity Female Hemodialysis Kidney disease |
| Zdroj: | International Journal of Pharmaceutics. 180:113-121 |
| ISSN: | 0378-5173 |
| Popis: | The migration of di-2-ethylhexyl phthalate (DEHP) from dialyzers was studied in 21 patients with chronic renal failure undergoing maintenance hemodialysis. The circulating concentrations of DEHP were measured by high performance liquid chromatography in blood of patients obtained from the inlet and the outlet of the dialyzer during a 4-h dialysis session. During treatment of renal failure using plasticized tubing, the plasma level of DEHP increased. On average, an estimated 75.2 mg of DEHP was extracted from the dialyzer during a single dialysis session, with a range of 44.3-197. 1 mg. On the other hand, the total amount of DEHP retained by the patient during the dialysis session was evaluated by the difference between the AUCout and the AUCin and ranged from 3.6 to 59.6 mg. The rate of extraction of DEHP from the dialyzer was correlated (r=0.705, P |
| Databáze: | OpenAIRE |
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