In situ gelling and dissolvable hydrogels for use as on-demand wound dressings for burns

Autor:	Nada Naguib, Ara Nazarian, Aaron H. Colby, Katherine Cook, Katherine Hohl, Mark W. Grinstaff, Robert L. Sheridan, Jack Kirsch, Edward K. Rodriguez
Rok vydání:	2021
Předmět:	In situ Burn wound integumentary system Chemistry On demand Mechanical strength Self-healing hydrogels Biomedical Engineering Second-Degree Burn General Materials Science Human skin Article Biomedical engineering
Zdroj:	Biomater Sci
ISSN:	2047-4849 2047-4830
DOI:	10.1039/d1bm00711d
Popis:	Currently, no dressings utilized in burn clinics provide adhesion, hydration or mechanical strength on the same order as human skin as well as the ability to be atraumatically removed. We report the synthesis, characterization, and in vivo evaluation of in situ polymerized and subsequent dissolvable hydrogels as burn wound dressings. Hydrogel dressings, from a small library of synthesized materials form in situ, exhibit storage moduli between 100-40,000 Pa, dissolve on-demand within 10 minutes to 90 minutes, swell up to 350%, and adhere to both burned and healthy human skin at 0.2-0.3N/cm(2). Further, results from an in vivo porcine second degree burn model demonstrate functional performance with healing equivalent to conventional treatments with the added benefit of facile, in situ application and subsequent removal via dissolution.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d46abd661438994eb9b6a8615b2d370 https://doi.org/10.1039/d1bm00711d Zobrazit plný text záznamu