Brevipedicelones D and E, Two C-O-C Flavonoid Dimmers from the Leaves of Garcinia brevipedicellata and Anti-onchocercal Activity
| Autor: | Bernard Bodo, A.E. Tih, Moses Samje, Mirabel Akongwi, Kennedy D. Nyongbela, Raphael T. Ghogomu |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult worm
Flavonoid Ethyl acetate Brevipedicelone Plant Science Toxicology 01 natural sciences Biochemistry Analytical Chemistry chemistry.chemical_compound Garcinia brevipedicellata lcsh:Botany parasitic diseases Spectral data Pharmacology chemistry.chemical_classification biology Traditional medicine 010405 organic chemistry Chemistry Organic Chemistry Onchocerca ochengi Biflavonoid biology.organism_classification 0104 chemical sciences lcsh:QK1-989 Anti-onchocercal activity 010404 medicinal & biomolecular chemistry Original Article Loa loa Food Science |
| Zdroj: | Natural Products and Bioprospecting Natural Products and Bioprospecting, Vol 9, Iss 1, Pp 61-68 (2018) |
| ISSN: | 2192-2195 |
| Popis: | A novel isoflavone–chromone flavonoid C–O–C dimmer, brevipedicelone D (1), along with one new C–O–C biflavonoid derivative, brevipedicelone E (2), were isolated from the ethyl acetate extract of the leaves of Garcinia brevipedicellata, a medicinal plant used in folk medicine in parts of Cameroon. Their structures were elucidated by extensive spectroscopic techniques, including 1D- and 2D- NMR, MS experiments, as well as comparing their spectral data with those of known analogues. Anti-onchocercal screening of 1 showed moderate inhibition of adult worm motility of Onchocerca ochengi by 60% at the highest concentration (20 µg/mL) and inhibited motility of both the juvenile worms of O. ochengi and Loa loa by 90% at this same concentration. Graphical Abstract Electronic supplementary material The online version of this article (10.1007/s13659-018-0191-9) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink