Antistaphylococcal activity and beta-lactamase resistance of newer cephalosporins
| Autor: | Gramling Pk, Farrar We |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Staphylococcus aureus
Meticillin medicine.drug_class medicine.medical_treatment Penicillin Resistance Cephalosporin Cefazolin Microbial Sensitivity Tests medicine.disease_cause Microbiology Amidohydrolases polycyclic compounds medicine Cephaloridine Immunology and Allergy Humans Cefamandole Cefoxitin Cephalosporinase Dose-Response Relationship Drug Chemistry Hydrolysis Penicillin G Staphylococcal Infections bacterial infections and mycoses Cephalosporins Infectious Diseases Beta-lactamase medicine.drug |
| Zdroj: | The Journal of infectious diseases. 133(6) |
| ISSN: | 0022-1899 |
| Popis: | Four newer cephalosporins (cefazolin, cefamandole, SK&F 59962, and cefoxitin) were investigated for determination of their antistaphylococcal activity and relative stability to staphylococcal beta-lactamase (penicillinase). Crude preparations of beta-lactamase from recent clinical isolates of Staphylococcus aureus were used. Cefamandole and SK&F 59962 were highly active against both large and small inocula of staphylococci and were resistant to staphylococcal beta-lactamase. Cefoxitin, although resistant to beta-lactamase, possessed less antibacterial potency but was still approximately as active as methicillin. Cefazolin was somewhat more susceptible to staphylococcal beta-lactamase than the other three agents and resembled cephaloridine in this respect. With minor exceptions, a correlation was found between the susceptibility of different agents to beta-lactamase and the magnitude of the effect of inoculum size when the drugs were tested against large and small inocula of staphylococci. |
| Databáze: | OpenAIRE |
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