Molecular Tweezers: Supramolecular Hosts with Broad-Spectrum Biological Applications
| Autor: | Shahpasand-Kroner, Hedieh, Siddique, Ibrar, Malik, Ravinder, Linares, Gabriel R., Ivanova, Magdalena I., Ichida, Justin, Weil, Tatjana, Müunch, Jan, Sanchez-Garcia, Elsa, Klärner, Frank-Gerrit, Schrader, Thomas, Bitan, Gal, Münch, Jan |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Pharmacological Reviews. 75:263-308 |
| ISSN: | 1521-0081 0031-6997 |
| Popis: | Lysine-selective molecular tweezers (MTs) are supramolecular host molecules displaying a remarkably broad spectrum of biological activities. MTs act as inhibitors of the self-assembly and toxicity of amyloidogenic proteins using a unique mechanism. They destroy viral membranes and inhibit infection by enveloped viruses, such as HIV-1 and SARS-CoV-2, by mechanisms unrelated to their action on protein self-assembly. They also disrupt biofilm of Gram-positive bacteria. The efficacy and safety of MTs have been demonstrated |
| Databáze: | OpenAIRE |
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