Effects of local acidosis on vascular resistance in dog skeletal muscle
| Autor: | J. L. Parker, Thomas E. Emerson, G. W. Jelks |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Male
medicine.medical_specialty Hydrogen ion Vasodilation Acetates Sodium Chloride General Biochemistry Genetics and Molecular Biology Dogs Internal medicine Isotonic medicine Animals Acidosis Constant flow business.industry Muscles Skeletal muscle Anatomy Arteries Hydrogen-Ion Concentration Perfusion Endocrinology medicine.anatomical_structure Blood Hematocrit Vascular resistance Lactates Female Vascular Resistance medicine.symptom Isotonic Solutions business Blood ph |
| Zdroj: | Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 145(1) |
| ISSN: | 0037-9727 |
| Popis: | SummaryExperiments were completed in collateral free, constant flow perfused dog gracilis muscles to determine the effects of local increases in H+ on skeletal muscle vascular resistance. Blood pH was decreased step-wise by intraarterial infusions of isotonic lactic or acetic acid solutions. A decrease in pH with either of these acids was associated with a step-wise decrease in muscle vascular resistance. While it was clearly demonstrated that hydrogen ion is vasodilator in skeletal muscle, the H+ effect appears to be too small to account for the substantial decrease in resistance characteristic of active or reactive hyperemia.This research was supported in part by Grants from the Michigan Heart Association and NIH (HE10899). The authors are grateful for the technical assistance of Scott Underwood and Robert Young. |
| Databáze: | OpenAIRE |
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