Defining B cell immunodominance to viruses
| Autor: | Adrian B. McDermott, Adam K. Wheatley, Gregory M. Frank, Suman R. Das, Heather D. Hickman, Jonathan W. Yewdell, Ivan Kosik, Davide Angeletti, Matthew Angel, Madhu Prabhakaran, David J. Leggat, James S. Gibbs |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
biology business.industry Immunology Priming (immunology) Immunodominance medicine.disease_cause Article 03 medical and health sciences 030104 developmental biology Immune system medicine.anatomical_structure Antigen Immunity Influenza A virus medicine biology.protein Immunology and Allergy Antibody business B cell |
| Zdroj: | Nature immunology |
| ISSN: | 1529-2916 1529-2908 |
| Popis: | Immunodominance defines the hierarchical immune response to competing antigens in complex immunogens. Little is known regarding B cell and antibody immunodominance despite its importance to immunity to viruses and other pathogens. We show that B cells and serum antibodies from inbred mice demonstrate a reproducible immunodominance hierarchy to the five major antigenic sites in the influenza A virus hemagglutinin globular domain. The hierarchy changes as the immune response progresses and depending on antigen formulation and delivery. Passive antibody transfer and sequential infection experiments demonstrate “original antigenic suppression”, where antibodies suppress memory responses to the priming antigenic site. Our study provides a template for attaining deeper understanding of antibody immunodominance to viruses and other immunogens. |
| Databáze: | OpenAIRE |
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