Autoimmune thrombocytopenia related to chronic hepatitis C virus infection
| Autor: | Elisabeth Lampe, Carlos Eduardo Brandão-Mello, C. L. Antonietti, R. de Vasconcellos Carvalhaes de Oliveira, Clara F. T. Yoshida, M. P. do Espírito-Santo, Marilza Campos-de-Magalhães, A. J. de Almeida, M. L. P. da Silva |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Hepatitis C virus Platelet Membrane Glycoproteins Interferon alpha-2 medicine.disease_cause Platelet membrane glycoprotein Antiviral Agents Antibodies Virus Autoimmune thrombocytopenia Polyethylene Glycols Immune system Ribavirin medicine Humans Platelet Prospective Studies Aged biology Platelet Count business.industry Interferon-alpha Hematology Hepatitis C Chronic Middle Aged Virology Recombinant Proteins Pathophysiology Immunology biology.protein Drug Therapy Combination Female Anemia Hemolytic Autoimmune Antibody business |
| Zdroj: | Hematology. 14:49-58 |
| ISSN: | 1607-8454 |
| Popis: | Since the identification of hepatitis C virus (HCV) in 1989 as a causative agent for a number of the extrahepatic alterations related to HCV infection an underlying immune mediated pathogenetic mechanism has been postulated. HCV-associated thrombocytopenia may be considered complex and multifactorial in origin, since different mechanisms have been implicated in its pathophysiology. With respect to autoimmune thrombocytopenia in chronic HCV infection, the detection of specific antibodies against platelet glycoproteins have been reported only in a few studies, but no systematic study has been carried out. We examined the clinical, laboratory, and virological characteristics of a case series of 10 patients with autoimmune thrombocytopenia (platelet count150.0 x 10(9)/L) related to chronic HCV infection. Cases, six males and four females, aged 57.1 +/- 12.6 years, presented high titers of antibodies against platelet glycoprotein (GP) IIb/IIIa, GP Ia/IIa, and/or GP Ib/IX, and no other mechanism involved in the pathogenesis of HCV-associated thrombocytopenia was identified. Furthermore, cases were not associated with particular HCV genotype. Complete platelet response was observed in two patients treated with pegylated interferon plus ribavirin, and partial platelet response was seen in two patients treated with anti-D Ig and one patient treated with corticosteroids. These findings indicate that an autoimmune mechanism may play a role in the pathogenesis of HCV-associated thrombocytopenia in a proportion of these patients. |
| Databáze: | OpenAIRE |
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