Linezolid-resistant Staphylococcus epidermidis associated with long-term, repeated linezolid use in a pediatric patient
| Autor: | Hidemasa Ochiai, Mari Matsui, Keigo Shibayama, Akiko Takaya, Tomoko Yamamoto, Masaharu Watanabe, Naruhiko Ishiwada, Asahi Kimura, Moeko Hino |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Microbiology (medical) 030106 microbiology Microbial Sensitivity Tests Staphylococcal infections Microbiology 03 medical and health sciences chemistry.chemical_compound Fatal Outcome Staphylococcus epidermidis 23S ribosomal RNA Resistant strain Drug Resistance Bacterial Humans Medicine heterocyclic compounds Pharmacology (medical) Linezolid resistance Child biology business.industry organic chemicals Linezolid Staphylococcal Infections biochemical phenomena metabolism and nutrition bacterial infections and mycoses biology.organism_classification medicine.disease Anti-Bacterial Agents Leukemia Myeloid Acute Pediatric patient Infectious Diseases chemistry Bacteremia bacteria Female business |
| Zdroj: | Journal of Infection and Chemotherapy. 22:187-190 |
| ISSN: | 1341-321X |
| DOI: | 10.1016/j.jiac.2015.10.004 |
| Popis: | We report an 8-year-old patient with catheter-related bacteremia caused by linezolid-resistant Staphylococcus epidermidis that was isolated after the long-term, repeated use of linezolid. Three S. epidermidis strains isolated from this patient were bacteriologically analyzed. While the strain isolated prior to linezolid initiation was susceptible to linezolid, two strains after linezolid therapy displayed low-level linezolid susceptibility (MIC, 4 mg/L) and linezolid resistance (MIC, 16 mg/L). T2500A mutation in two copies and G2575T mutations in three copies of 23S rRNA were detected in the low-susceptible strain and the resistant strain, respectively. Linezolid-resistant S. epidermidis infection is rare, but may occur with the long-term administration of linezolid. |
| Databáze: | OpenAIRE |
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