The psychological impact of IVF failure after two or more cycles of IVF with a mild versus standard treatment strategy
| Autor: | M.J.C. Eijkemans, Bart C.J.M. Fauser, Nick S. Macklon, Jan Passchier, C. de Klerk, J.A.M. Hunfeld, E.M.E.W. Heijnen |
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| Přispěvatelé: | Psychiatry, Obstetrics & Gynecology, Public Health |
| Rok vydání: | 2007 |
| Předmět: |
Adult
medicine.medical_specialty medicine.drug_class medicine.medical_treatment Fertilization in Vitro Anxiety Hospital Anxiety and Depression Scale Gonadotropin-releasing hormone antagonist law.invention Gonadotropin-Releasing Hormone Randomized controlled trial Ovulation Induction law Internal medicine medicine Humans Sperm Injections Intracytoplasmic Treatment Failure Depression (differential diagnoses) Netherlands Gynecology In vitro fertilisation business.industry Depression Standard treatment Rehabilitation Obstetrics and Gynecology Embryo Transfer Embryo transfer Reproductive Medicine Ovulation induction Female business Infertility Female |
| Zdroj: | Human Reproduction, 22(9), 2554-2558. Oxford University Press |
| ISSN: | 0268-1161 |
| Popis: | BACKGROUND: Failure of IVF treatment after a number of cycles can be devastating for couples. Although mild IVF strategies reduce the psychological burden of treatment, failure may cause feelings of regret that a more aggressive approach, including the transfer of two embryos, was not employed. In this study, the impact of treatment failure after two or more cycles on stress was studied, following treatment with a mild versus a standard treatment strategy. METHODS: Randomized controlled two-centre trial (ISRCTN35766970). Women were randomized to undergo mild ovarian stimulation (including GnRH antagonist co-treatment) and single embryo transfer (n 5 197) or standard GnRH agonist long-protocol ovarian stimulation with double embryo transfer (n 5 194). Participants completed the Hospital Anxiety and Depression Scale prior to commencing treatment and 1 week after the outcome of their final treatment cycle was known. Data from women who underwent two or more IVF cycles were subject to analysis (n 5 253). RESULTS: Women who experienced treatment failure after standard IVF treatment presented more symptoms of depression 1 week after treatment termination compared with women who had undergone mild IVF: adjusted mean (+ +95% confidence interval)510.2 (+2.3) versus 5.4 (+1.8), respectively, P 5 0.01. CONCLUSIONS: Failure of IVF treatment after a mild treatment strategy may result in fewer short-term symptoms of depression as compared to failure after a standard treatment strategy. These findings may further encourage the application of mild IVF treatment strategies in clinical practice. |
| Databáze: | OpenAIRE |
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