Global Prevalence of Asymptomatic Norovirus Infection: A Meta-analysis
| Autor: | Cong Chen, Hui-Ju Han, Wenqian Li, Xiang-Rong Qin, Li-Jun Wang, Yue Sun, Yu-ting Huang, Min Zhao, Jun-hong Li, Rui Qi, Xi-feng Sun, Jian-Wei Liu, Xue-Jie Yu |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
030106 microbiology Summary data Context (language use) medicine.disease_cause Asymptomatic 03 medical and health sciences 0302 clinical medicine Prevalence Medicine 030212 general & internal medicine lcsh:R5-920 High prevalence business.industry Transmission (medicine) Norovirus Outbreak General Medicine Meta-analysis medicine.symptom business lcsh:Medicine (General) Demography Research Paper |
| Zdroj: | EClinicalMedicine, Vol 2, Iss, Pp 50-58 (2018) EClinicalMedicine |
| ISSN: | 2589-5370 |
| Popis: | Background Studies about asymptomatic norovirus infections have been frequently reported. We aim to assess the global prevalence of asymptomatic infections. Method We identified publications that included the proportion of asymptomatic norovirus infections by searching in PubMed, Ovid, Scopus, and Web of Science and by screening references from the articles reviewed. The principal summary data were the prevalence of asymptomatic norovirus infection. Random-effect models for meta-analysis were fitted to generate estimates of overall and subgroup prevalence. Findings Of 81 studies included, asymptomatic norovirus prevalence was estimated at 7% (95% CI: 6%–9%). Africa, Meso America and South America had higher prevalence (15%, 14%, 11%, respectively) while the prevalence in Europe and North America was lower (4%). Prevalence was similar between community and hospital (9%). Prevalence was higher in children (8%) than adults (4%). For food handlers, prevalence was estimated at 3%. In context of outbreaks, prevalence estimated from 15 studies was as high as 18% (95% CI: 10%–30%). Interpretation This knowledge could have an impact on the development of transmission prevention strategies in the future. The high prevalence indicated asymptomatic individuals must not be overlooked. Outstanding questions The high prevalence indicated asymptomatic individuals must not be overlooked. Asymptomatic individuals may play an important role in norovirus transmission. This knowledge could have an impact on the development of transmission prevention strategies. Highlights • A pooled analysis of global prevalence from 36 countries was conducted. • Global prevalence of asymptomatic norovirus infection is about 7%. • Prevalence of asymptomatic norovirus infection varies among countries. |
| Databáze: | OpenAIRE |
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