Endothelial nitric oxide synthase gene Glu298Asp polymorphism and blood pressure, left ventricular mass and carotid artery atherosclerosis in a population-based cohort
| Autor: | Markku J. Ikäheimo, Markku Päivänsalo, Jarkko Karvonen, Markku J. Savolainen, Kari Kervinen, Heikki Kauma, Maire Rantala, Y. A. Kesäniemi |
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| Rok vydání: | 2002 |
| Předmět: |
Male
Risk medicine.medical_specialty Genotype Heart disease Endothelium Population Glutamic Acid Blood Pressure Nitric Oxide Cohort Studies Gene Frequency Internal medicine Internal Medicine medicine Humans Carotid Stenosis education Allele frequency Alleles Finland Aspartic Acid education.field_of_study Polymorphism Genetic business.industry Case-control study Middle Aged medicine.disease Cross-Sectional Studies Genetics Population Blood pressure Endocrinology medicine.anatomical_structure Case-Control Studies Hypertension Cohort Cardiology Population study Female Hypertrophy Left Ventricular Endothelium Vascular Nitric Oxide Synthase business |
| Zdroj: | Journal of Internal Medicine. 251:102-110 |
| ISSN: | 1365-2796 0954-6820 |
| Popis: | Karvonen J, Kauma H, Kervinen K, Rantala M, Ikaheimo M, Paivansalo M, Savolainen MJ, Kesaniemi YA (University of Oulu, Oulu; Finland). Endothelial nitric oxide synthase gene Glu298Asp polymorphism and blood pressure, left ventricular mass and carotid artery atherosclerosis in a population-based cohort. J Intern Med 2002; 251: 102–110. Objective. Decreased production of endothelial nitric oxide (NO) is associated with different cardiovascular pathology. We studied the association between the Glu298Asp polymorphism of the NO producing gene, endothelial nitric oxide synthase (eNOS), and hypertension, left ventricular mass (LVM) and carotid artery intima-media thickness (IMT) in a population-based cohort of hypertensive and control subjects. Design. Cross-sectional case–control study. Setting. District around Oulu University Hospital, Northern Finland. Subjects and methods. The study population consisted of 600 middle-aged hypertensive subjects (300 men and 300 women) and 600 controls (300 men and 300 women) living in the City of Oulu. The hypertensive subjects were randomly selected by age stratification from the Social Insurance Institute register for reimbursement of antihypertensive medication. For each hypertensive subject, an age- and sex-matched control was randomly selected from the national health register. The overall participation rate was 87.8%. In the present study a total of 1024 subjects were screened. Echocardiographic examinations were performed by a trained cardiologist and carotid ultrasonographic examinations by a trained radiologist. Results. The genotype distributions and allele frequencies between the hypertensive and control subjects and the relationship between the Glu298Asp variant and blood pressure, LVM and carotid artery IMT were determined. No differences in genotype distribution or allele frequencies were found between the hypertensive and control groups (the frequency of the Asp allele 0.299 vs. 0.288, respectively). Also, we could not find any association between the eNOS genotype and the measured cardiovascular complications. Conclusions. The Glu298Asp variant of the eNOS gene does not seem to be a major risk factor for cardiovascular alterations in the general population. |
| Databáze: | OpenAIRE |
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