A tryptic digestion fragment of nerve growth factor with nerve growth promoting activity
| Autor: | R. Revoltella, D. Mercanti, R. Butler |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Male
Neurite Biophysics Peptide Chick Embryo Biology Biochemistry Mice chemistry.chemical_compound Animals Trypsin Cyanogen Bromide Nerve Growth Factors Amino Acids Molecular Biology Peptide sequence chemistry.chemical_classification Fragment (computer graphics) Embryo Molecular biology Peptide Fragments Nerve growth factor chemistry Ganglia Cyanogen bromide Digestion |
| Zdroj: | Biochimica et Biophysica Acta (BBA) - General Subjects. 496:412-419 |
| ISSN: | 0304-4165 |
| DOI: | 10.1016/0304-4165(77)90323-3 |
| Popis: | A peptide, isolated from the acid-insoluble portion of a tryptic digest of cyanogen bromide cleaved nerve growth factor, favors life maintenance of sensory target cells and promotes rapid neurite outgrowth from 7-day-old chick embryo sensory ganglia. The fragment has been identified as a 30 amino acid peptide consisting of two linear oligipeptides linked by a disulphide bridge and corresponding to residues 10–25 and 75–88 of the amino acid sequence of nerve growth factor. On a molar basis the fragment is about 100 times more effective than intact nerve growth factor. Other peptides isolated from the digest are biologically inactive. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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