Investigating the Effects of Surface-Initiated Polymerization of ε-Caprolactone to Bioactive Glass Particles on the Mechanical Properties of Settable Polymer/Ceramic Composites
| Autor: | Scott A. Guelcher, Joseph C. Wenke, Andrew J. Harmata, Katarzyna J. Zienkiewicz, Catherine L. Ward |
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| Rok vydání: | 2015 |
| Předmět: |
chemistry.chemical_classification
Materials science Mechanical Engineering Surface initiated Composite number Polymer Condensed Matter Physics Article law.invention chemistry.chemical_compound Compressive strength chemistry Polymerization Mechanics of Materials law visual_art Bioactive glass visual_art.visual_art_medium General Materials Science Ceramic Composite material Caprolactone |
| Zdroj: | Journal of materials research. 29(20) |
| ISSN: | 0884-2914 |
| Popis: | Injectable bone grafts with strength exceeding that of trabecular bone could improve the clinical management of a number of orthopedic conditions. Ceramic/polymer composites have been investigated as weight-bearing bone grafts, but they are typically weaker than trabecular bone due to poor interfacial bonding. We hypothesized that entrapment of surface-initiated poly(e-caprolactone) (PCL) chains on 45S5 bioactive glass (BG) particles within an in situ-formed polymer network would enhance the mechanical properties of reactive BG/polymer composites. When the surface-initiated PCL molecular weight exceeded the molecular weight between crosslinks of the network, the compressive strength of the composites increased 6- to 10-fold. The torsional strength of the composites exceeded that of human trabecular bone by a factor of two. When injected into femoral condyle defects in rats, the composites supported new bone formation at 8 weeks. The initial bone-like strength of BG/polymer composites and their ability to remodel in vivo highlight their potential for development as injectable grafts for repair of weight-bearing bone defects. |
| Databáze: | OpenAIRE |
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