Basic butylated methacrylate copolymer/kappa-carrageenan interpolyelectrolyte complex: Preparation, characterization and drug release behaviour
| Autor: | Héctor J. Prado, Pablo Ricardo Bonelli, Ana Lea Cukierman, M.C. Matulewicz |
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| Rok vydání: | 2008 |
| Předmět: |
Surface Properties
Chemistry Pharmaceutical Drug Compounding Pharmaceutical Science Ibuprofen Carrageenan Dosage form Matrix (chemical analysis) chemistry.chemical_compound Adsorption Polymethacrylic Acids medicine Technology Pharmaceutical Organic chemistry Particle Size Porosity Drug Carriers Chemistry Anti-Inflammatory Agents Non-Steroidal General Medicine Hydrogen-Ion Concentration Controlled release Kinetics Models Chemical Solubility Chemical engineering Delayed-Action Preparations Particle size Swelling medicine.symptom Tablets Biotechnology |
| Zdroj: | European Journal of Pharmaceutics and Biopharmaceutics. 70:171-178 |
| ISSN: | 0939-6411 |
| DOI: | 10.1016/j.ejpb.2008.04.017 |
| Popis: | The formation of a novel interpolyelectrolyte complex (IPEC) between basic butylated methacrylate copolymer and kappa-carrageenan was investigated and the product formed was characterized. Turbidity measurements and elemental analyses pointed to a 1:1 interaction of the repeating units. These results and FT-IR confirmed IPEC formation. Electronic microscopy images, particle size determination by image analysis and N2 (77 K) adsorption measurements were consistent with a porous material. This IPEC formed presented very good flowability and compactibility. Two maxima were observed in the swelling behaviour as a function of pH. The performance of the IPEC as a matrix for controlled release of drugs was evaluated, using ibuprofen as a model drug. Release profiles were properly represented by a mathematical model, which indicates that the system releases ibuprofen in a zero-order manner. These profiles could be controlled by conveniently modifying the proportion of the IPEC in the tablets. |
| Databáze: | OpenAIRE |
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