Enhanced activity of pyramidal neurons in the infralimbic cortex drives anxiety behavior

Autor: Olivia Andrea Masseck, Josephine Eckardt, Laura Berg
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
Male
Emotions
Social Sciences
Anxiety
Biochemistry
Synaptic Transmission
Mice
0302 clinical medicine
Animal Cells
Medicine and Health Sciences
Psychology
Prefrontal cortex
Neurons
Mammals
Mice
Knockout
Multidisciplinary
Animal Behavior
Chemistry
Pyramidal Cells
Brain
Eukaryota
Neurochemistry
Neurotransmitters
Amygdala
Anxiety Disorders
medicine.anatomical_structure
Vertebrates
Receptor
Serotonin
5-HT1A
Medicine
medicine.symptom
Cellular Types
Anatomy
Proto-Oncogene Proteins c-fos
Research Article
Dorsal Raphe Nucleus
Biogenic Amines
Serotonin
Science
Infralimbic cortex
Prefrontal Cortex
Mice
Transgenic
Neurotransmission
Optogenetics
Stimulus (physiology)
Inhibitory postsynaptic potential
Rodents
03 medical and health sciences
Interneurons
medicine
Animals
Humans
Behavior
Organisms
Biology and Life Sciences
Cell Biology
Disease Models
Animal
030104 developmental biology
Cellular Neuroscience
Amniotes
Neuroscience
Zoology
030217 neurology & neurosurgery
Zdroj: PLoS ONE
PLoS ONE, Vol 14, Iss 1, p e0210949 (2019)
ISSN: 1932-6203
Popis: We show that in an animal model of anxiety the overall excitation, particularly in the infralimbic region of the medial prefrontal cortex (IL), is increased and that the activity ratio between excitatory pyramidal neurons and inhibitory interneurons (AR PN/IN) is shifted towards excitation. The same change in AR PN/IN is evident for wildtype mice, which have been exposed to an anxiety stimulus. We hypothesize, that an elevated activity and the imbalance of excitation (PN) and inhibition (IN) within the neuronal microcircuitry of the prefrontal cortex is responsible for anxiety behaviour and employed optogenetic methods in freely moving mice to verify our findings. Consistent with our hypothesis elevation of pyramidal neuron activity in the infralimbic region of the prefrontal cortex significantly enhanced anxiety levels in several behavioural tasks by shifting the AR PN/IN to excitation, without affecting motor behaviour, thus revealing a novel mechanism by which anxiety is facilitated.
Databáze: OpenAIRE
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