Critical determinants of nonspatial working memory deficits in rats with conventional lesions of the hippocampus or fornix
| Autor: | J. N. P. Rawlins, G. L. Lyford, A. Seferiades, R. M. J. Deacon, H. J. Cassaday |
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| Jazyk: | angličtina |
| Rok vydání: | 1993 |
| Předmět: | |
| Zdroj: | Behavioral neuroscience. 107(3) |
| ISSN: | 1939-0084 0735-7044 |
| Popis: | Rats with conventional lesions of the hippocampus or fornix were compared postoperatively with controls on nonspatial memory tasks. Neither lesion impaired delayed matching-to-sample (DMS) performance in a discrete-trial task involving "pseudo-trial-unique" complex stimuli. An impairment emerged if a single pair of complex stimuli was used throughout each day's session, and the greatest impairment was obtained with the use of a single pair of less complex stimuli throughout each day's test. Transfer to a continuous DMS task with no explicit intertrial interval produced a different pattern because both lesion and control levels of performance were depressed when two complex stimuli were used repeatedly. A final, separate discrimination learning experiment showed that hippocampectomized rats readily discriminated between the stimuli associated with the greatest lesion-induced DMS deficit. Hippocampal dysfunction thus produces clear deficits on non-spatial memory tasks under appropriate test conditions. |
| Databáze: | OpenAIRE |
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