Iodide-Selective Synthetic Ion Channels Based on Shape-Persistent Organic Cages
| Autor: | In-Chul Hwang, Rumum Rohman, Pulakesh Aich, Younghoon Kim, Kyung Lock Kim, Kimoon Kim, Joon Ho Roh, Soonsang Hong, Bahiru Punja Benke, Eun Hui Lee |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
chemistry.chemical_classification
010405 organic chemistry Inorganic chemistry Iodide Dynamic covalent chemistry General Chemistry 010402 general chemistry Photochemistry 01 natural sciences Biochemistry Porphyrin Catalysis 0104 chemical sciences chemistry.chemical_compound Colloid and Surface Chemistry Membrane chemistry Covalent bond Synthetic ion channels Iodide transport Ion channel |
| Zdroj: | Journal of the American Chemical Society. 139:7432-7435 |
| ISSN: | 1520-5126 0002-7863 |
| DOI: | 10.1021/jacs.7b02708 |
| Popis: | We report here a synthetic ion channel developed from a shape-persistent porphyrin-based covalent organic cage. The cage was synthesized by employing a synthetically economical dynamic covalent chemistry (DCC) approach. The organic cage selectively transports biologically relevant iodide ions over other inorganic anions by a dehydration-driven, channel mechanism as evidenced by vesicle-based fluorescence assays and planar lipid bilayer-based single channel recordings. Furthermore, the organic cage appears to facilitate iodide transport across the membrane of a living cell, suggesting that the cage could be useful as a biological tool that may replace defective iodide channels in living systems. |
| Databáze: | OpenAIRE |
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