Pure pineal germinomas: analysis of gender incidence
| Autor: | V. Cuccia, M. Galarza |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Male
endocrine system Pathology medicine.medical_specialty Adolescent medicine.medical_treatment Argentina Pineal Gland Drug Therapy Antineoplastic Combined Chemotherapy Protocols Biopsy medicine Humans Sex Distribution Child Neuroradiology Radiotherapy medicine.diagnostic_test Germinoma business.industry Incidence (epidemiology) medicine.disease Magnetic Resonance Imaging Cerebrospinal Fluid Shunts Cranial Nerve Diseases Hydrocephalus Radiation therapy Treatment Outcome Female Surgery Neurology (clinical) Germ cell tumors Neurosurgery Intracranial Hypertension Neoplasm Recurrence Local Tomography X-Ray Computed business Pinealoma |
| Zdroj: | Acta Neurochirurgica. 148:865-871 |
| ISSN: | 0942-0940 0001-6268 |
| Popis: | Objective. Pure pineal germinomas have been rarely reported in girls. Gender incidence and differences of pure pineal germinomas are not well known. The authors report a series of pure pineal germinoma and its gender characteristic is reviewed. Methods and Results. Of a total of 50 germ cell tumors operated on between 1988 and 2004 we found 26 cases (median age at diagnosis, 12 years) of pineal germ cell tumors. Of these, 14 cases (male/female ratio: 13/1) were pure pineal germinomas, and 12 cases (male/female ratio: 12/0) were non-germinoma germ cell tumors. In pure pineal germinomas, the main clinical presentations were intracranial hypertension and cranial nerve dysfunction. Imaging studies disclosed a homogeneous type of tumor (n = 10) and associated hydrocephalus (n = 6). Cases were managed with biopsy and subsequent radiation therapy and chemotherapy. After a follow up of 10 years, pure germinoma cases have no neurological deficits and tumor recurrence. The literature on gender incidence of pure pineal germinomas is analyzed and possible causes are discussed. Conclusions. Although rare, pure pineal germinoma can be found in female subjects. On the basis of the literature review, the male/female ratio in cases of pure pineal germinoma is between 5:1 and 22:1 (mean 14:1). In our series, the male/female ratio was 13:1. |
| Databáze: | OpenAIRE |
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