Effects of CYP3A5 Polymorphism on Rapid Progression of Chronic Kidney Disease: A Prospective, Multicentre Study
| Autor: | Hin-Seng Wong, Aina Yazrin Ali Nasiruddin, Sunita Bavanandan, Mohd Makmor-Bakry, Shamin Mohd Saffian, Nurul Ain Mohd Tahir, Abdul Halim Abdul Gafor, Farida Hanim Islahudin, Fei Yee Lee, Adyani Md Redzuan |
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| Rok vydání: | 2021 |
| Předmět: |
CYP3A5
medicine.medical_specialty 030232 urology & nephrology lcsh:Medicine Medicine (miscellaneous) Renal function urologic and male genital diseases Logistic regression Article clinical translation polymorphism 03 medical and health sciences 0302 clinical medicine Polymorphism (computer science) Internal medicine Medicine 030212 general & internal medicine Prospective cohort study pharmacogenomics business.industry lcsh:R Confounding Odds ratio medicine.disease female genital diseases and pregnancy complications Confidence interval progression business chronic kidney disease Kidney disease |
| Zdroj: | Journal of Personalized Medicine Volume 11 Issue 4 Journal of Personalized Medicine, Vol 11, Iss 252, p 252 (2021) |
| ISSN: | 2075-4426 |
| Popis: | Personalised medicine is potentially useful to delay the progression of chronic kidney disease (CKD). The aim of this study was to determine the effects of CYP3A5 polymorphism in rapid CKD progression. This multicentre, observational, prospective cohort study was performed among adult CKD patients (≥18 years) with estimated glomerular filtration rate (eGFR) ≥30 mL/min/1.73 m2, who had ≥4 outpatient, non-emergency eGFR values during the three-year study period. The blood samples collected were analysed for CYP3A5*3 polymorphism. Rapid CKD progression was defined as eGFR decline of > 5 mL/min/1.73 m2/year. Multiple logistic regression was then performed to identify the factors associated with rapid CKD progression. A total of 124 subjects consented to participate. The distribution of the genotypes adhered to the Hardy–Weinberg equilibrium (X2 = 0.237, p = 0.626). After adjusting for potential confounding factors via multiple logistic regression, the factors associated with rapid CKD progression were CYP3A5*3/*3 polymorphism (adjusted Odds Ratio [aOR] 4.190, 95% confidence interval [CI]: 1.268, 13.852), adjustments to antihypertensives, young age, dyslipidaemia, smoking and use of traditional/complementary medicine. CKD patients should be monitored closely for possible factors associated with rapid CKD progression to optimise clinical outcomes. The CYP3A5*3/*3 genotype could potentially be screened among CKD patients to offer more individualised management among these patients. |
| Databáze: | OpenAIRE |
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