Near-infrared fluorescent 9-phenylethynylpyronin analogues for bioimaging
| Autor: | Petr Klán, Peter Štacko, Tomáš Pastierik, Jiřina Medalová, Peter Šebej |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Absorption (pharmacology)
Spectroscopy Near-Infrared Silicon Organic Chemistry Near-infrared spectroscopy chemistry.chemical_element Photochemistry Fluorescence Molecular Imaging chemistry.chemical_compound chemistry In vivo Nanoparticles Pyronine Methanol Molecular imaging Spectroscopy Fluorescent Dyes |
| Zdroj: | The Journal of organic chemistry. 79(8) |
| ISSN: | 1520-6904 |
| Popis: | The syntheses and biological applications of two novel fluorescent 9-phenylethynylpyronin analogues containing either carbon or silicon at the position 10 are reported. Both fluorescent probes exhibited a relatively strong fluorescence in methanol and phosphate buffer saline in the near-infrared region (705–738 nm) upon irradiation of either of their absorption maxima in the blue and red regions. The compounds showed high selectivity toward mitochondria in myeloma cells in vivo and allowed their visualization in a favored tissue-transparent window, which makes them promising NIR fluorescent tags for applications in bioimaging. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|