Effects of coenzyme Q10 supplementation on C-reactive protein and homocysteine as the inflammatory markers in hemodialysis patients; a randomized clinical trial
| Autor: | Narges Sadat Zahed, Maryam Ghassami, Hajar Nikbakht |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Hyperhomocysteinemia
medicine.medical_specialty Homocysteine medicine.medical_treatment Placebo medicine.disease_cause Gastroenterology C-reactive protein Coronary artery disease chemistry.chemical_compound Internal medicine medicine Renal insufficiency Coenzyme Q10 biology business.industry medicine.disease Surgery chemistry Nephrology biology.protein Original Article Hemodialysis business Oxidative stress |
| Zdroj: | Journal of Nephropathology |
| ISSN: | 2251-8819 2251-8363 |
| DOI: | 10.15171/jnp.2016.07 |
| Popis: | Background: The most leading cause of death in end-stage renal disease (ESRD) patients are cardiovascular disease and inflammatory markers are related to coronary events. CO-Q10 (coenzyme Q10) is a protective supplement from free radical oxidative damage. In addition, hyperhomocysteinemia is an independent coronary artery disease (CAD) risk factor. Objectives: Due to increasing oxidative stress in dialysis patients, and the effect of CO-Q10 in decrease oxidative stress, in this work, we assessed the effect of CO-Q10 on C-reactive protein (CRP) level as an inflammatory marker and homocysteine in dialysis patients. Patients and Methods: This was a single-blind, randomized cross over clinical trial. Patients with ESRD were randomly allotted to two groups. All patients received placebo and C0- Q10 100mg/d during the three months in each stage, with two week washout period. Plasma level of CRP and homocysteine from the start of the work and at the conclusion of each menses, are evaluated. Results: Thirty-four patients randomized, but 26 patients complete study protocol. The treatment effect of CO-Q10 on CRP level is significant (P < 0.001) (95% CI = -20.1 to -10.5) and it was also significant for the increasing albumin level. (P = 0.044) (95% CI = 0. 0-0.6), But there was not any substantial effect on serum homocysteine level (P = 0.630). Conclusions: CO-Q10 could significantly decrease CRP level as an inflammatory marker and can protect cardiovascular events. |
| Databáze: | OpenAIRE |
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