Vascular Effects of Ultrafine Particles in Persons with Type 2 Diabetes

Autor: Judith C. Stewart, Steven M. Lee, David Chalupa, Li-Shan Huang, Mark J. Utell, Lauren M. Frasier, Mark W. Frampton, Richard P. Phipps, Anthony P. Pietropaoli, Robert B. Devlin, Mark B. Taubman, Erika L. Little
Rok vydání: 2010
Předmět:
Male
Health
Toxicology and Mutagenesis
air pollution
Type 2 diabetes
030204 cardiovascular system & hematology
010501 environmental sciences
01 natural sciences
0302 clinical medicine
vascular
Sex factors
Ultrafine particle
Air Pollutants
Cross-Over Studies
diabetes
Inhalation
Systemic Vasculitis
Age Factors
Middle Aged
3. Good health
P-Selectin
platelets
Female
Elemental carbon
Adult
medicine.medical_specialty
CD40 Ligand
Young Adult
03 medical and health sciences
Sex Factors
Double-Blind Method
Air pollutants
Internal medicine
von Willebrand Factor
medicine
Humans
Platelet activation
0105 earth and related environmental sciences
Coagulants
business.industry
Research
Public Health
Environmental and Occupational Health
medicine.disease
Carbon
ultrafine particles
Endocrinology
Increased risk
Diabetes Mellitus
Type 2
Immunology
Blood Vessels
Particulate Matter
business
Zdroj: Environmental Health Perspectives
ISSN: 1552-9924
0091-6765
DOI: 10.1289/ehp.1002237
Popis: Background Diabetes confers an increased risk for cardiovascular effects of airborne particles. Objective We hypothesized that inhalation of elemental carbon ultrafine particles (UFP) would activate blood platelets and vascular endothelium in people with type 2 diabetes. Methods In a randomized, double-blind, crossover trial, 19 subjects with type 2 diabetes inhaled filtered air or 50 μg/m3 elemental carbon UFP (count median diameter, 32 nm) by mouthpiece for 2 hr at rest. We repeatedly measured markers of vascular activation, coagulation, and systemic inflammation before and after exposure. Results Compared with air, particle exposure increased platelet expression of CD40 ligand (CD40L) and the number of platelet-leukocyte conjugates 3.5 hr after exposure. Soluble CD40L decreased with UFP exposure. Plasma von Willebrand factor increased immediately after exposure. There were no effects of particles on plasma tissue factor, coagulation factors VII or IX, or D-dimer. Conclusions Inhalation of elemental carbon UFP for 2-hr transiently activated platelets, and possibly the vascular endothelium, in people with type 2 diabetes.
Databáze: OpenAIRE
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