The influence of timing of systemic ketamine administration on postoperative morphine consumption
| Autor: | Tufan Bilgin, Nesimi Uckunkaya, Abit Toker, Selcan Osma, Hülya Bilgin, Berin Özcan, Tijen Alev, Beklen Kerimoglu |
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| Přispěvatelé: | Uludağ Üniversitesi/Tıp Fakültesi/Anesteziyoloji Anabilim Dalı., Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı., Bilgin, Hülya, Özcan, Berin, Bilgin, Tufan, Kerimoğlu, Beklen, Uçkunkay, Nesimi, Toker, Abit, Alev, Tijen, Osma, Selcan, A-7338-2016 |
| Rok vydání: | 2005 |
| Předmět: |
Adult
medicine.medical_specialty Time Factors Visual analogue scale medicine.medical_treatment Analgesic Pain Sodium Chloride Drug Administration Schedule Preemptive analgesia Gynecologic Surgical Procedures Anesthesiology Laparotomy medicine Humans Anesthesia Ketamine Prospective Studies Dosing Postoperative Saline Pain Measurement Postoperative Pain Anesthetic Agent Analgesics Pain Postoperative Dose-Response Relationship Drug Morphine business.industry Preemptive Requirements Analgesia Patient-Controlled Central sensitization Middle Aged Rats Surgery Analgesics Opioid Anesthesiology and Pain Medicine Hyperalgesia Small-dose ketamine Female Analgesia business Surgical incision medicine.drug |
| Zdroj: | Journal of Clinical Anesthesia. 17:592-597 |
| ISSN: | 0952-8180 |
| DOI: | 10.1016/j.jclinane.2005.04.005 |
| Popis: | Study Objective: To determine the influence of timing of systemic ketamine administration on postoperative morphine consumption. Design: Prospective randomized study. Setting: Operating rooms, postanesthesia care unit, and gynecology service of a university hospital. Patients: Forty-five patients undergoing laparotomy for benign gynecologic pathologies were randomized into 3 groups. Interventions: In Group 1, before surgical incision. patients received 0.5 mg/kg ketamine IV, followed by normal saline infusion and normal saline IV at wound closure in group 1 (n = 15). In group 2 (n = 15), patients received 0.5 mg/kg ketamine IV before surgery, followed by ketamine infusion 600 mu g kg(-1) (.) h(-1), until wound closure and normal saline IV at that time, In the other group (group 3, n = 15), patients received normal saline IV before surgery, followed by saline infusion and then 0.5 mg/kg ketamine IV at wound closure. In the postoperative period, patient-controlled analgesia TV morphine was used for postoperative pain relief. First requested analgesic medication time was recorded. Postoperative pain was assessed by measuring morphine consumption at 0 to 2, 0 to 4, and 0 to 24 hours and visual analog scale (VAS) pain scores in response to cough at 2nd, 4th. and 24th hours and during rest at 0 to 2, 0 to 4, and 0 to 24 hours after surgery. Measurement and Main Results: First requested analgesia was shorter in group 1 than the others (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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