Effects of fluticasone propionate inhalation on levels of arachidonic acid metabolites in patients with chronic obstructive pulmonary disease
| Autor: | Freek J. Zijlstra, Ingrid M. Garrelds, Henk C. Hoogsteden, Gert T. Verhoeven |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2001 |
| Předmět: |
Adult
medicine.medical_specialty Immunology Anti-Inflammatory Agents Placebo-controlled study Placebo Fluticasone propionate Double-Blind Method Internal medicine medicine lcsh:Pathology Humans Lung Diseases Obstructive Asthma Fluticasone COPD Arachidonic Acid medicine.diagnostic_test Inhalation business.industry Smoking Cell Biology Middle Aged respiratory system medicine.disease Respiratory Function Tests respiratory tract diseases Androstadienes Endocrinology Bronchoalveolar lavage business Bronchoalveolar Lavage Fluid Research Article medicine.drug lcsh:RB1-214 |
| Zdroj: | Mediators of Inflammation, Vol 10, Iss 1, Pp 21-26 (2001) Mediators of Inflammation |
| ISSN: | 1466-1861 0962-9351 |
| Popis: | Background: In smoking COPD patients the bronchoalveolar lavage (BAL) fluid contains high numbers of inflammatory cells. These cells might produce arachidonic acid (AA) metabolites, which contribute to inflammation and an increased bronchomotor tone.Aims: To investigate levels of AA metabolites in BAL fluid, before and after inhaled glucocorticoid therapy: fluticasone propionate (FP) 1mg per day, or placebo.Methods: A double-blind placebo controlled trial lasting six months. COPD patients were selected by clinical criteria and the presence of bronchial hyperresponsiveness (BHR). Lung function was recorded and in BAL fluid we counted cell numbers and measured LTB4, LTC4/D4/E4, PGE2, 6kPGF1α , PGF2α and TxB2. A control group consisted of asymptomatic smokers(n=6).Results: Paired data were obtained from 9 FP treated and 11 placebo patients. BAL cells were almost exclusively alveolar macrophages. In patients and controls both cellularity and levels of AA metabolites were equal. Cell numbers did not change after treatment. Statistically significant decreases after FP therapy were noticed for PGE2(30%), 6kPGF1α (41%) and PGF2α (54%).Conclusions: In COPD, the capability of inflammatory cells to produce certain AA metabolites was decreased after inhaled FP treatment. This result is discussed in its relation to clinical effects, the influence of smoking, and the results of an earlier, similar study in asthma patients. |
| Databáze: | OpenAIRE |
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