Recovery of decreased metabotropic glutamate receptor 5 availability in abstinent alcohol-dependent patients
| Autor: | H Peuskens, Gil Leurquin-Sterk, Guy Bormans, Cleo L. Crunelle, Bart de Laat, Koen Van Laere, Jenny Ceccarini |
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| Přispěvatelé: | Faculty of Medicine and Pharmacy, Psychiatry |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Pyridines Receptor Metabotropic Glutamate 5 media_common.quotation_subject Hippocampus Craving Nucleus accumbens 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Ethyl glucuronide Internal medicine Nitriles mental disorders medicine Humans Radiology Nuclear Medicine and imaging mGluR5 media_common Computer. Automation Metabotropic glutamate receptor 5 business.industry Alcohol Abstinence Alcohol dependence Middle Aged Abstinence 030227 psychiatry Alcoholism Endocrinology chemistry nervous system Radiology Nuclear Medicine and imaging Positron-Emission Tomography alcohol craving Female alcohol addiction medicine.symptom business 030217 neurology & neurosurgery Follow-Up Studies |
| Zdroj: | The Journal of nuclear medicine |
| ISSN: | 0161-5505 |
| Popis: | Animal models of alcohol dependence and relapse demonstrate an important role of the glutamatergic system, in particular the cerebral metabotropic glutamate receptor 5 (mGluR5). Using [18F]FPEB positron emission tomography, it was found that chronic alcohol use leads to decreased limbic mGluR5 availability, where lower mGluR5 was associated with less craving. Here, we tested whether the state of decreased mGluR5 availability in alcohol-dependent patients normalizes during abstinence (at 2- and 6-month of detoxification) and whether initial mGluR5 imaging parameters can predict individual relapse. Methods: [18F]FPEB scans were performed in 16 recently detoxified alcohol-dependent patients (baseline condition), after 2 months (n = 10) and 6 months (n = 8) of detoxification, in comparison to 32 age- and gender-matched controls. mGluR5 availability was quantified by [18F]FPEB total distribution volume using both voxel-by-voxel and volume-of-interest analysis. During follow-up, craving was assessed using the Desire for Alcohol Questionnaire, and alcohol consumption was assessed by a Time-Line Follow Back and monitored by hair ethyl glucuronide analysis. Results: During abstinence, alcohol-dependent patients showed a sustained recovered mGluR5 availability in cortical and subcortical regions (pheight |
| Databáze: | OpenAIRE |
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