Microbial transformation ofN-heptyl physostigmine, a semisynthetic alkaloid inhibitor of cholinesterase
| Autor: | Byron H. Arison, M S Schwartz, Tom S. Chen, Richard L. Monaghan, Raymond F. White, H Cheng, B. Petuch, Lydia T. So |
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| Rok vydání: | 1995 |
| Předmět: |
Physostigmine
biology Acremonium Alkaloid Metabolite Bioengineering biology.organism_classification Applied Microbiology and Biotechnology chemistry.chemical_compound chemistry Biochemistry Enzyme inhibitor biology.protein medicine Cholinesterase Inhibitors Mitosporic Fungi Actinomycetales Actinoplanes Biotransformation Biotechnology Cholinesterase medicine.drug |
| Zdroj: | Journal of Industrial Microbiology. 15:108-111 |
| ISSN: | 1476-5535 0169-4146 |
| DOI: | 10.1007/bf01569808 |
| Popis: | The microbiological transformation of N-heptyl physostigmine (L-693,487) (1), a semisynthetic physostigmine cholinesterase inhibitor, was investigated using Verticillium lecanii MF 5713 (ATCC 74148), Acremonium sp MF 5723 (ATCC 74164) and Actinoplanes sp MA 6559 (ATCC 53771). Nine microbial metabolites (2-10) of 1 were isolated and purified using reversed-phase HPLC. The structures of the metabolites were established using spectroscopic techniques including MS and NMR. Some of the microbial metabolites were identical to metabolites present in urine of a dog treated with 1. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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