The influence of aircraft noise exposure on the systemic and renal haemodynamics
Autor: | Kristina Striepe, Marina V. Karg, Christian Ott, Agnes Bosch, Dennis Kannenkeril, Susanne Jung, Roland E. Schmieder |
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Rok vydání: | 2020 |
Předmět: |
Male
medicine.medical_specialty Aircraft Epidemiology Cardiac index Hemodynamics Renal function 030204 cardiovascular system & hematology Kidney Renal Circulation 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans 030212 general & internal medicine Renal circulation medicine.diagnostic_test business.industry Impedance cardiography medicine.anatomical_structure Renal blood flow Vascular resistance Cardiology Cardiology and Cardiovascular Medicine business Electrocardiography Glomerular Filtration Rate |
Zdroj: | European journal of preventive cardiology. 29(1) |
ISSN: | 2047-4881 |
Popis: | Aims Epidemiological studies found a link between aircraft noise exposure and increased incidence of arterial hypertension and cardiovascular disease, but the underlying pathophysiological mechanisms are not fully understood. Clinical studies have shown that mental stress affects the systemic and renal haemodynamic, but no such study was performed with noise exposure as stress factor. We analysed systemic and renal effects of 25 min standardized aircraft noise in a sham controlled clinical study including 80 healthy men and 34 male patients with hypertension. Methods and results Systemic haemodynamic parameters were measured using electrocardiography and impedance cardiography. The renal haemodynamic was assessed using steady state input clearance with infusion of para-aminohippuric acid and inulin for glomerular filtration rate and renal plasma flow, respectively. In the systemic circulation of hypertensive patients, there was an increase in total peripheral resistance (TPR) (1420 ± 387 vs. 1640 ± 516 dyn·s·cm−5, P = 0.001) and a decrease in cardiac index (CI) (2.9 ± 0.8 vs. 2.6 ± 0.8 L/(min·m2, P Conclusions In hypertensive but not healthy men we observed a systemic vasoconstrictive response after aircraft noise exposure accompanied by a decrease in CI. No significant changes were observed in the renal circulation. Our results suggest that male hypertensive patients are more susceptible for noise-induced changes of vascular resistance in the systemic circulation. |
Databáze: | OpenAIRE |
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