Central versus local radiological reading of acute computed tomography characteristics in multi-center traumatic brain injury research
| Autor: | R.H.M.A. Bartels, Paul M. Parizel, Thomas Van Essen, Daniel Kondziella, Maria A. Poca, Juan Sahuquillo, Oliver Sakowitz, Rafael Badenes, Johnny Collett, Lars Wessels, Angelos Kolias, Ana M Castaño-Leon, Thijs Vande Vyvere, Morten Blaabjerg, Giuseppe Citerio, Rahul Raj, Linda Lanyon, Edgar Santos, Jussi Posti, Renán Sánchez-Porras, Andreea Rădoi, Sandra Rossi, Pedro Gomez, Virginia Newcombe, William Stewart, Jonathan Coles, Diederik Dippel, Helen Dawes, Arminas Ragauskas |
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| Přispěvatelé: | Vande Vyvere, T, Wilms, G, Claes, L, Martin Leon, F, Nieboer, D, Verheyden, J, Van Den Hauwe, L, Pullens, P, Maas, A, Parizel, P, Citerio, G, CENTER-TBI Investigators, Molecular Neuroscience and Ageing Research (MOLAR), Section Neuropsychology, Psychiatrie & Neuropsychologie, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, RS: FPN NPPP I, Public Health, Neurosurgery, Vande Vyvere, Thij, Wilms, Guido, Claes, Lene, Martin Leon, Francisco, Nieboer, Daan, Verheyden, Jan, van den Hauwe, Luc, Pullens, Pim, Maas, Andrew I R, Parizel, Paul M, Beretta, Luigi |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
030506 rehabilitation
medicine.medical_specialty Subarachnoid hemorrhage Traumatic brain injury FEATURES Other Research Radboud Institute for Molecular Life Sciences [Radboudumc 0] DIAGNOSIS HEMORRHAGE 03 medical and health sciences 0302 clinical medicine McNemar's test Cohen's kappa Midline shift Brain Injuries Traumatic medicine Humans Observer Variation central radiology review business.industry Research traumatic brain injury Head injury agreement central radiology review traumatic brain injury HEAD-INJURY Brain Reproducibility of Results COMMON DATA ELEMENTS medicine.disease ta3124 PROGNOSTIC VALUE Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10] Radiological weapon Human medicine Neurology (clinical) Radiology Tomography X-Ray Computed 0305 other medical science business agreement SCAN 030217 neurology & neurosurgery Kappa CT |
| Zdroj: | Journal of neurotrauma Journal of Neurotrauma, 36(7), 1080-1092. MARY ANN LIEBERT, INC Journal of Neurotrauma, 36, 7, pp. 1080-1092 Journal of Neurotrauma, 36(7), 1080-1092. Mary Ann Liebert Inc. JOURNAL OF NEUROTRAUMA r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA instname Journal of Neurotrauma, 36(7), 1080-92. Mary Ann Liebert Inc. Journal of Neurotrauma, 36, 1080-1092 |
| ISSN: | 1557-9042 0897-7151 |
| Popis: | Contains fulltext : 206372.pdf (Publisher’s version ) (Closed access) Observer variability in local radiological reading is a major concern in large-scale multi-center traumatic brain injury (TBI) studies. A central review process has been advocated to minimize this variability. The aim of this study is to compare central with local reading of TBI imaging datasets and to investigate the added value of central review. A total of 2050 admission computed tomography (CT) scans from subjects enrolled in the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study were analyzed for seven main CT characteristics. Kappa statistics were used to calculate agreement between central and local evaluations and a center-specific analysis was performed. The McNemar test was used to detect whether discordances were significant. Central interobserver and intra-observer agreement was calculated in a subset of patients. Good agreement was found between central and local assessment for the presence or absence of structural pathology (CT+, CT-, kappa = 0.73) and most CT characteristics (kappa = 0.62 to 0.71), except for traumatic axonal injury lesions (kappa = 0.37). Despite good kappa values, discordances were significant in four of seven CT characteristics (i.e., midline shift, contusion, traumatic subarachnoid hemorrhage, and cisternal compression; p = 0.0005). Central reviewers showed substantial to excellent interobserver and intra-observer agreement (kappa = 0.73 to kappa = 0.96), contrasted by considerable variability in local radiological reading. Compared with local evaluation, a central review process offers a more consistent radiological reading of acute CT characteristics in TBI. It generates reliable, reproducible data and should be recommended for use in multi-center TBI studies. |
| Databáze: | OpenAIRE |
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