Apoptotic and inflammation markers in oral mucositis in head and neck cancer patients receiving radiotherapy: preliminary report
| Autor: | Anastasia Sotiropoulou-Lontou, P. Athanassiadou, John Kouvaris, Efstratios Patsouris, Ourania Nicolatou-Galitis, George Pissakas, Arsinoi A Xanthinaki, Vassilis Kouloulias, Maria Gonidi, Konstantinos Kyprianou |
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| Rok vydání: | 2007 |
| Předmět: |
Oncology
Adult Male medicine.medical_specialty medicine.medical_treatment Interleukin-1beta Inflammation Apoptosis Pilot Projects Severity of Illness Index Risk Factors Internal medicine Severity of illness Mucositis Biomarkers Tumor Medicine Humans Karnofsky Performance Status Aged Aged 80 and over Stomatitis Radiotherapy business.industry Tumor Necrosis Factor-alpha Head and neck cancer Middle Aged medicine.disease Immunohistochemistry Radiation therapy Proto-Oncogene Proteins c-bcl-2 Head and Neck Neoplasms Myeloid Cell Leukemia Sequence 1 Protein Tumor necrosis factor alpha Female medicine.symptom business |
| Zdroj: | Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer. 16(9) |
| ISSN: | 0941-4355 |
| Popis: | The aim of this study was to investigate the expression of pro-apoptotic protein p53 and anti-apoptotic proteins BCl-2 and MCl-1, as well as the expression of pro-inflammatory cytokines tumor necrosis factor (TNF) and interleukin-1beta (IL-1beta) in patients developing mucositis during radiotherapy for head and neck cancer.Thirty-five patients receiving radiotherapy for head/neck cancer were included in this study. Patients were examined before radiotherapy. Oral mucositis was recorded weekly during radiotherapy. Cytologic smears from the oral cavity were taken with a brush. Immunocytochemical staining was performed by the use of p53, BCl-2, MCl-1 TNF and IL-1beta monoclonal antibodies.P53 was expressed in 1 of 15 smears before the initiation of radiotherapy (6.5%) compared to 3 of 7 smears from patients with grade III mucositis (43%) during radiotherapy. BCl-2 was expressed in 15 of 15 smears before radiotherapy (100%) and in three of seven patients with grade III mucositis (43%) during radiotherapy. MCl-1 was expressed in 10 of 14 samples before radiotherapy (71.5%) and in two of seven patients with grade III (28.5%) mucositis during radiotherapy. TNF was expressed in 9 of 14 patients before radiotherapy (64%) and in six of seven patients with grade III mucositis during radiotherapy (86%). IL-1beta was detected in 7 of 14 patients before radiotherapy (50%) compared to 6 of 7 patients with grade III mucositis during radiotherapy (86%).Our preliminary results indicate an induction of apoptosis and inflammation in the oral mucosa in patients developing mucositis during radiotherapy for head/neck cancer. |
| Databáze: | OpenAIRE |
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