Association of systolic blood pressure and pulse pressure with carotid intima thickness in elderly Japanese patients

Autor:	Takunori Seki, Susumu Ohmori, Daisuke Maebuchi, Mitsuhiro Tominaga, Osamu Kohno, Emi Oishi, Shuntaro Kagiyama, Mitsuo Iida
Rok vydání:	2013
Předmět:	Male medicine.medical_specialty Physiology Coefficient of variation Diastole Blood Pressure Carotid imt Positive correlation Carotid Intima-Media Thickness Asian People Japan Risk Factors Internal medicine Diabetes mellitus Internal Medicine medicine Humans cardiovascular diseases Risk factor Aged Aged 80 and over business.industry General Medicine musculoskeletal system medicine.disease Pulse pressure Endocrinology Blood pressure Cardiovascular Diseases Hypertension cardiovascular system Cardiology Regression Analysis Female business
Zdroj:	Clinical and experimental hypertension (New York, N.Y. : 1993). 35(4)
ISSN:	1525-6006
Popis:	Many studies have demonstrated that increased carotid intima-media thickness (IMT) is related to future cardiovascular events and is influenced by cardiovascular risk factors such as sex, hypertension, diabetes, and hypercholesterolemia. Although aging is a well-known risk factor for an increase in carotid IMT, few studies have investigated which factors influence carotid IMT in the very elderly. In the present study, we investigated the relationship of pulse pressure (PP), blood pressure (BP), and its variability (six consecutive visits) with carotid IMT among 240 high-risk elderly in whom risk factors were managed clinically (average age was 79 ± 5 years). In the simple correlation, mean systolic BP (SBP) had a positive correlation with IMT and max IMT (P = .012 and P = .045), as did PP (P = .018 and P = .004), but did not diastolic BP or standard deviation of BP and coefficient of variation of BP. In multiple regression analyses, mean SBP and mean PP were each determinants of both IMT and max IMT, when each parameter was added separately to the regression model. We concluded that high SBP and wide PP still have an influence on increased carotid IMT in the very elderly Japanese patients.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d2e8accfb8a9fecb3f126c7c2bdf6f9 https://pubmed.ncbi.nlm.nih.gov/23772871 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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