Clinical and diagnostic aspects of intestinal microsporidiosis in HIV-infected patients with chronic diarrhea in Rio de Janeiro, Brazil
| Autor: | Siudomar Pereira da Silva, Fernando C. Sodré, Maria Stella de Castro Lobo, Marisa G. Morgado, Edson Jurado da Silva, Erika Verissimo Villela, Hercules Moura, Patrícia Brasil, Dirce Bonfim de Lima, Daurita Darci de Paiva, José Mauro Peralta |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Diarrhea Male medicine.medical_specialty Prevalence HIV Infections Microsporidiosis Gastroenterology Polymerase Chain Reaction Statistics Nonparametric Cohort Studies Feces fluids and secretions Acquired immunodeficiency syndrome (AIDS) Internal medicine Biopsy medicine Animals Humans Enterocytozoon bieneusi biology medicine.diagnostic_test business.industry virus diseases General Medicine medicine.disease biology.organism_classification Virology Microscopy Electron Infectious Diseases Microsporidia Chronic Disease Female medicine.symptom business Brazil Follow-Up Studies |
| Zdroj: | Revista do Instituto de Medicina Tropical de Sao Paulo. 42(6) |
| ISSN: | 0036-4665 |
| Popis: | The objectives of this study were to determine both the prevalence of microsporidial intestinal infection and the clinical outcome of the disease in a cohort of 40 HIV-infected patients presenting with chronic diarrhea in Rio de Janeiro, Brazil. Each patient, after clinical evaluation, had stools and intestinal fragments examined for viral, bacterial and parasitic pathogens. Microsporidia were found in 11 patients (27.5%) either in stools or in duodenal or ileal biopsies. Microsporidial spores were found more frequently in stools than in biopsy fragments. Samples examined using transmission electron microscopy (n=3) or polymerase chain reaction (n=6) confirmed Enterocytozoon bieneusi as the causative agent. Microsporidia were the only potential enteric pathogens found in 5 of the 11 patients. Other pathogens were also detected in the intestinal tract of 21 patients, but diarrhea remained unexplained in 8. We concluded that microsporidial infection is frequently found in HIV infected persons in Rio de Janeiro, and it seems to be a marker of advanced stage of AIDS. |
| Databáze: | OpenAIRE |
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