Observational Registry of Basal Insulin Treatment (ORBIT) in patients with type 2 diabetes uncontrolled with oral antihyperglycaemic drugs: Real-life use of basal insulin in China
| Autor: | Zhiguang Zhou, Puhong Zhang, Linong Ji, Weiping Jia, Wenying Yang, Xiaohui Guo, Dongshan Zhu, Xian Li, Jiachao Ji, Yangfeng Wu, Chang-yu Pan, Juming Lu, Dajin Zou, Yan Gao, Jianping Weng, Satish K. Garg |
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| Rok vydání: | 2017 |
| Předmět: |
Blood Glucose
Male China medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment 030209 endocrinology & metabolism Type 2 diabetes 030204 cardiovascular system & hematology Hypoglycemia 03 medical and health sciences 0302 clinical medicine Endocrinology Internal medicine Internal Medicine medicine Humans Hypoglycemic Agents Registries Aged Glycated Hemoglobin business.industry Insulin glargine Insulin Basal insulin Type 2 Diabetes Mellitus Middle Aged medicine.disease Surgery Insulin Long-Acting Treatment Outcome Diabetes Mellitus Type 2 Drug Therapy Combination Female Observational study medicine.symptom business Weight gain medicine.drug |
| Zdroj: | Diabetes, Obesity and Metabolism. 19:822-830 |
| ISSN: | 1462-8902 |
| DOI: | 10.1111/dom.12886 |
| Popis: | To examine treatment patterns following basal insulin (BI) introduction in type 2 diabetes mellitus (T2DM) patients under real-world conditions across China.Overall, 18 995 patients inadequately controlled (HbA1c ≥ 53 mmol/mol [7%]) with oral antihyperglycaemic drugs (OADs) and willing to receive BI treatment were registered at 209 hospitals and followed at baseline (visit 1), 3 months (visit 2) and 6 months (visit 3). Type of BI was initiated at physicians' discretion.Retention with BI therapy at 6 months was 75.6%. Use of long-acting BI predominated, with insulin glargine accounting for 71%, detemir 13% and Neutral Protamine Hagedorn (NPH) insulin 16%. Over 70% of long-acting users maintained the same initial BI at visit 3, while 40% of NPH users switched treatment and 24.4% of participants initiated BI with prandial insulin. The initial mean (± SD) dose of BI and total insulin was 0.18 ± 0.07 and 0.25 ± 0.19 IU/kg, respectively, with a mean increase of daily dose by 0.03 and 0.02 IU/kg after 6 months, respectively. Only 56.6% of insulin users reported dose titration at visit 3. Mean HbA1c was 81 mmol/mol (9.6%) at baseline and 57 mmol/mol (7.4%) at 6 months. The frequency of hypoglycaemia was 1.61 and 2.07 episodes/patient-year at baseline and 6 months, respectively.In real-world clinical settings, add-on BI therapy in T2DM patients is associated with significant improvement in glycaemic control without overtly compromising safety related to hypoglycaemia and weight gain. Evolution of insulin treatment regimens varied among patients, but dose titration was suboptimal. More active BI dose titration might further improve glycaemic outcome in patients receiving BI therapy.A free Video Abstract to accompany this article is available at https://vimeo.com/212655959. |
| Databáze: | OpenAIRE |
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