Evaluation of trace element concentration in cancerous and non-cancerous tissues of human stomach
| Autor: | Farshad Sheikhesmaili, Hozan Loqmani, Behzad Shahmoradi, Ramesh Rahehagh, Afshin Maleki, Ebrahim Ghaderi, Ebrahim Mohammadi, Shadi Kohzadi, Baran Parhizkar |
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| Rok vydání: | 2017 |
| Předmět: |
Pathology
medicine.medical_specialty Environmental Engineering Health Toxicology and Mutagenesis Analytical chemistry Iran 010501 environmental sciences medicine.disease_cause 01 natural sciences 03 medical and health sciences 0302 clinical medicine Stomach Neoplasms Blood plasma Biopsy medicine Humans Environmental Chemistry Carcinogen 0105 earth and related environmental sciences medicine.diagnostic_test Chemistry Spectrum Analysis Stomach Public Health Environmental and Occupational Health Cancer Environmental Exposure General Medicine General Chemistry Environmental exposure medicine.disease Pollution Trace Elements medicine.anatomical_structure Gastric Mucosa 030220 oncology & carcinogenesis Environmental Pollutants Carcinogenesis Copper Oxidative stress |
| Zdroj: | Chemosphere. 184:747-752 |
| ISSN: | 0045-6535 |
| DOI: | 10.1016/j.chemosphere.2017.06.071 |
| Popis: | Gastric cancer has a high mortality rate in west of Iran. Various environmental elements are proposed as cancer risk factors including trace elements. Trace elements can induce initiation or progression of carcinogenesis via oxidative stress and DNA injury. The aim of this study was to measure and compare some trace element concentration (Ca, Cu, Fe, As, Mg, Ni, Cd and Cr) in gastric cancer tissues and normal tissues. For this purpose, 35 patients with gastric cancer and 30 without any cancer were biopsied. Biopsies were taken from cancerous tissue and non-cancerous tissue of gastric cancer patients and gastric tissue of normal patients. The analysis of trace elements was performed using Inductively coupled plasma mass spectrometry (ICP-MS). Data analysis was carried out using SPSS and STATA 12 software. The research found that the concentrations of Fe, Mg, and As were higher in cancerous tissues compared with non-cancerous tissues whereas Cr, Cu, Ca, and Ni concentrations were higher in non-cancerous tissues of cancerous patients. When comparisons were made for cancer and normal samples, copper was the only metal, which was significantly higher in cancerous samples (p |
| Databáze: | OpenAIRE |
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